Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort.

Autor: Salvador-Martín S; Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Zapata-Cobo P; Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Velasco M; Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain., Palomino LM; Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain., Clemente S; Hospital Vall d'Hebrón, 08035 Barcelona, Spain., Segarra O; Hospital Vall d'Hebrón, 08035 Barcelona, Spain., Sánchez C; Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Tolín M; Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Moreno-Álvarez A; Hospital Universitario A Coruña, 15006 A Coruña, Spain., Fernández-Lorenzo A; Hospital Universitario A Coruña, 15006 A Coruña, Spain., Pérez-Moneo B; Hospital Universitario Infanta Leonor, 28031 Madrid, Spain., Loverdos I; Hospital Universitario Parc Taulí, 08208 Sabadell, Spain., Navas López VM; Hospital Regional Universitario de Málaga, 29011 Málaga, Spain., Millán A; Hospital Universitario Virgen de Valme, Universidad de Sevilla, 41014 Sevilla, Spain., Magallares L; Hospital Universitario la Paz, 28046 Madrid, Spain., Torres-Peral R; Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain., García-Romero R; Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain., Pujol-Muncunill G; Servicio de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital Sant Joan de Dèu, 08950 Barcelona, Spain., Merino-Bohorquez V; Hospital Universitario Virgen de la Macarena, 41009 Sevilla, Spain., Rodríguez A; Hospital Universitario Virgen del Rocio, 41013 Sevilla, Spain., Salcedo E; Hospital Universitario Doce de Octubre, 28041 Madrid, Spain., López-Cauce B; Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Marín-Jiménez I; Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain., Menchén L; Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain., Laserna-Mendieta E; Departamento of Gastroenterología, Hospital General de Tomelloso, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 28029 Madrid, Spain.; Instituto de Investigación Sanitaria La Princesa, 28006 Madrid, Spain., Lucendo AJ; Departamento of Gastroenterología, Hospital General de Tomelloso, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 28029 Madrid, Spain., Sanjurjo-Sáez M; Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., López-Fernández LA; Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 16; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 16.
DOI: 10.3390/ijms24021797
Abstrakt: The genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment in inflammatory bowel disease (IBD). The aim was to analyze the association between these variants and the long-term response to anti-TNF drugs in pediatric IBD. We performed an observational, multicenter, ambispective study in which we selected 340 IBD patients under 18 years of age diagnosed with IBD and treated with anti-TNF drugs from a network of Spanish hospitals. Genotypes and failure of anti-TNF drugs were analyzed using Kaplan-Meier curves and Cox logistic regression. The homozygous G allele of rs2395185 and the C allele of rs2097432 were associated with impaired long-term response to anti-TNF drugs in children with IBD after 3 and 9 years of follow-up. Being a carrier of both polymorphisms increased the risk of anti-TNF failure. The SNP rs2395185 but not rs2097432 was associated with response to infliximab in adults with CD treated with infliximab but not in children after 3 or 9 years of follow-up. Conclusions: SNPs rs2395185 and rs2097432 were associated with a long-term response to anti-TNFs in IBD in Spanish children. Differences between adults and children were observed in patients diagnosed with CD and treated with infliximab.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje