| Autor: |
Dzhuzha AY; Institute of Chemistry, Saint-Petersburg State University, 198504 St. Petersburg, Russia.; Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia., Tarasenko II; Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia., Atanase LI; Faculty of Dental Medicine, 'Apollonia' University, 700399 Iasi, Romania., Lavrentieva A; Institute of Technical Chemistry, Gottfried-Wilhelm-Leibniz University, 30167 Hannover, Germany., Korzhikova-Vlakh EG; Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia. |
| Abstrakt: |
Synthetic poly(amino acids) are a unique class of macromolecules imitating natural polypeptides and are widely considered as carriers for drug and gene delivery. In this work, we synthesized, characterized and studied the properties of amphiphilic copolymers obtained by the post-polymerization modification of poly(α,L-glutamic acid) with various hydrophobic and basic L-amino acids and D-glucosamine. The resulting glycopolypeptides were capable of forming nanoparticles that exhibited reduced macrophage uptake and were non-toxic to human lung epithelial cells (BEAS-2B). Moreover, the developed nanoparticles were suitable for loading hydrophobic cargo. In particular, paclitaxel nanoformulations had a size of 170-330 nm and demonstrated a high cytostatic efficacy against human lung adenocarcinoma (A549). In general, the obtained nanoparticles were comparable in terms of their characteristics and properties to those based on amphiphilic (glyco)polypeptides obtained by copolymerization methods. |
