Violence against Women and Stress-Related Disorders: Seeking for Associated Epigenetic Signatures, a Pilot Study.

Autor:	Piccinini A; Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20100 Milan, Italy.; Service for Sexual and Domestic Violence( SVSeD), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20100 Milan, Italy., Bailo P; Section of Legal Medicine, School of Law, University of Camerino, 62032 Camerino, Italy., Barbara G; Service for Sexual and Domestic Violence( SVSeD), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20100 Milan, Italy.; Gynecology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20100 Milan, Italy.; Department of Clinical Sciences and Community Health, Università degli Studi di Milano di Milano, 20100 Milan, Italy., Miozzo M; Medical Genetics, Department of Health Sciences, Università degli Studi di Milano, 20100 Milan, Italy., Tabano S; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20100 Milan, Italy.; Medical Genetics Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20100 Milan, Italy., Colapietro P; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20100 Milan, Italy., Farè C; Medical Genetics Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20100 Milan, Italy., Sirchia SM; Medical Genetics, Department of Health Sciences, Università degli Studi di Milano, 20100 Milan, Italy., Battaglioli E; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, 20100 Milan, Italy., Bertuccio P; Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy., Manenti G; Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20100 Milan, Italy., Micci L; Service for Sexual and Domestic Violence( SVSeD), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20100 Milan, Italy., La Vecchia C; Department of Clinical Sciences and Community Health, Università degli Studi di Milano di Milano, 20100 Milan, Italy., Kustermann A; Service for Sexual and Domestic Violence( SVSeD), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20100 Milan, Italy., Gaudi S; Department of Environment and Health, Italian National Institute of Health, 00161 Rome, Italy.
Jazyk:	angličtina
Zdroj:	Healthcare (Basel, Switzerland) [Healthcare (Basel)] 2023 Jan 06; Vol. 11 (2). Date of Electronic Publication: 2023 Jan 06.
DOI:	10.3390/healthcare11020173
Abstrakt:	Background: Violence against women is a relevant health and social problem with negative consequences on women's health. The interaction between genome and environmental factors, such as violence, represents one of the major challenges in molecular medicine. The Epigenetics for WomEn (EpiWE) project is a multidisciplinary pilot study that intends to investigate the epigenetic signatures associated with intimate partner and sexual violence-induced stress-related disorders. Materials and Methods: In 2020, 62 women exposed to violence (13 women suffering from sexual violence and 49 from Intimate Partner Violence, IPV) and 50 women with no history of violence were recruited at the Service for Sexual and Domestic Violence. All women aged 18-65 were monitored for their physical and psychological conditions. Blood samples were collected, and DNAs were extracted and underwent the epigenetic analysis of 10 stress-related genes. Results: PTSD prevalence in victims was assessed at 8.1%. Quantitative methylation evaluation of the ten selected trauma/stress-related genes revealed the differential iper-methylation of brain-derived neurotrophic factor, dopamine receptor D2 and insulin-like growth factor 2 genes. These genes are among those related to brain plasticity, learning, and memory pathways. Conclusions: The association of early detection of posttraumatic distress and epigenetic marker identification could represent a new avenue for addressing women survivors toward resilience. This innovative approach in gender-based violence studies could identify new molecular pathways associated with the long-term effects of violence and implement innovative protocols of precision medicine.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu