| Autor: |
Khbouz B; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), 4000 Liège, Belgium.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Gu S; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), 4000 Liège, Belgium.; Zhongshan Hospital, Fudan University, Shanghai 200032, China., Pinto Coelho T; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), 4000 Liège, Belgium., Lallemand F; Cyclotron Research Center, University of Liège, 4000 Liège, Belgium.; Division of Radiotherapy, CHU of Liège, University of Liège (CHU ULiège), 4000 Liège, Belgium., Jouret F; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), 4000 Liège, Belgium.; Division of Nephrology, CHU of Liège, University of Liège (CHU ULiège), Avenue Hippocrate, 13, 4000 Liège, Belgium. |
| Abstrakt: |
Ionizing irradiation is widely applied as a fundamental therapeutic treatment in several diseases. Acute kidney injury (AKI) represents a global public health problem with major morbidity and mortality. Renal ischemia/reperfusion (I/R) is the main cause of AKI. I/R injury occurs when blood flow to the kidney is transiently interrupted and then restored. Such an ischemic insult significantly impairs renal function in the short and long terms. Renal ischemic preconditioning (IPC) corresponds to the maneuvers intended to prevent or attenuate the ischemic damage. In murine models, irradiation-induced preconditioning (IP) renders the renal parenchyma resistant to subsequent damage by activating defense pathways involved in oxidative stress, angiogenesis, and inflammation. Before envisioning translational applications in patients, safe irradiation modalities, including timing, dosage, and fractionation, need to be defined. |
