Sex-Specific Differences in Cytokine Induction by the Glycolipid Adjuvant 7DW8-5 in Mice.

Autor:	Watson FN; Graduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA 98109, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98109, USA.; Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA., Duncombe CJ; Graduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA 98109, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98109, USA.; Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA., Kalata AC; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98109, USA.; Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA., Conrad E; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98109, USA.; Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA., Chakravarty S; Sanaria Inc., 9800 Medical Center Drive, Suite A209, Rockville, MD 20850, USA., Sim BKL; Sanaria Inc., 9800 Medical Center Drive, Suite A209, Rockville, MD 20850, USA., Hoffman SL; Sanaria Inc., 9800 Medical Center Drive, Suite A209, Rockville, MD 20850, USA., Tsuji M; Aaron Diamond AIDS Research Center, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Shears MJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98109, USA.; Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA., Murphy SC; Graduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA 98109, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98109, USA.; Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.; Department of Microbiology, University of Washington, Seattle, WA 98109, USA.; Washington National Primate Research Center, University of Washington, Seattle, WA 98109, USA.; Department of Laboratories, Seattle Children's Hospital, Seattle, WA 98109, USA.
Jazyk:	angličtina
Zdroj:	Biomolecules [Biomolecules] 2022 Dec 21; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 21.
DOI:	10.3390/biom13010008
Abstrakt:	7DW8-5 is a potent glycolipid adjuvant that improves malaria vaccine efficacy in mice by inducing IFN-γ and increasing protective CD8 + T cell responses. The addition of 7DW8-5 was previously shown to improve the efficacy of a CD8 + T cell-mediated heterologous 'prime-and-trap' malaria vaccine against Plasmodium yoelii sporozoite challenge in inbred female mice. Here, we report significant differential sex-specific responses to 7DW8-5 in inbred and outbred mice. Male mice express significantly less IFN-γ and IL-4 compared to females following intravenous 7DW8-5 administration. Additionally, unlike in female mice, 7DW8-5 did not improve the vaccine efficacy against sporozoite challenge in prime-and-trap vaccinated male mice. Our findings highlight the importance of including both female and male sexes in experimental adjuvant studies.
Databáze:	MEDLINE
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