| Autor: |
Marginean CM; Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Cioboata R; Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Olteanu M; Department of Pneumology, University of Pharmacy and Medicine Craiova, 200349 Craiova, Romania., Vasile CM; Department of Pediatric and Adult Congenital Cardiology, Bordeaux University Hospital, 33600 Pessac, France., Popescu M; Department of Endocrinology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Popescu AIS; Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Bondari S; Department of Radiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Pirscoveanu D; Department of Neurology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Marginean IC; Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Iacob GA; Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Popescu MD; Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Stanciu M; Department of Endocrinology, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania., Mitrut P; Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. |
| Abstrakt: |
Among the most widespread childhood infections, Helicobacter pylori ( H. pylori ) develops potentially life-threatening conditions in adults if not appropriately treated. Helicobacter pylori is a common human pathogen that was first described in the stomach many years ago. The discovery of H. pylori was crucial in gastroenterology; this bacterium is associated with chronic gastritis, peptic ulcers, gastric cancer, and lymphoid tissue lymphoma related to the gastric mucosa. Studies published so far estimate that approximately 10% of subjects infected with H. pylori develop a peptic ulcer, and 1-3% of subjects develop gastric cancer. The clinical manifestations are variable and characteristically depend on the individual factors of the host. Various methods of detection and diagnosis of H. pylori infection have been developed, each with advantages, disadvantages, and/or limitations. Available diagnostic tests are usually performed using invasive (endoscopy, biopsy, rapid urease test, cultures, and molecular tests) and noninvasive methods (urea breath test, stool antigen examination, and serological and molecular tests). Although there is extensive accessibility for diagnosing and treating H. pylori infection, the prevalence of antibiotic resistance is not negligible. Thus, numerous studies and meta-analyses are focused on a new orientation of gastroenterologists in diagnosing and treating H. pylori infections. A fascinating perspective hypothesis is the administration of probiotics to reduce H. pylori adhesion to gastric epithelial cells, preventing H. pylori colonization, especially in children, or reinfection with H. pylori in high-risk adult patients. |
