| Autor: |
Karuniawati A; Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia., Ambarwulan M; Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia., Shahab SN; Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia., Moenadjat Y; Department of Surgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia., Lalisang TJM; Department of Surgery, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia., Kurniati ND; Department of Medical Microbiology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia., Kuntaman; Department of Medical Microbiology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia., Budipramana VS; Division of Digestive Surgery, Department of Surgery, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia., Lesmana T; Division of Digestive Surgery, Department of Surgery, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia., Puspitasari I; Dr. Kariadi General Hospital, Semarang 50244, Indonesia., Prabowo E; Dr. Kariadi General Hospital, Semarang 50244, Indonesia., Sasmitasari DPC; Faculty of Medicine, Diponegoro University, Semarang 502775, Indonesia., Putri DO; Faculty of Medicine, Diponegoro University, Semarang 502775, Indonesia., Badawi A; Global Medical Scientific Affair, Merck Sharp & Dohme (MSD), Jakarta 10220, Indonesia. |
| Abstrakt: |
Complicated intra-abdominal infections (cIAIs) lead to high morbidity and mortality, especially if poorly managed. However, Indonesia's microbial pattern and susceptibility data are limited, especially for new antibiotics. Ceftolozane/tazobactam (C/T) is reported to be a new potent antibiotic against various pathogens. Thus, we aim to investigate C/T in vitro activity against clinical isolates from cIAI patients. This prospective cross-sectional study was conducted in three major referral hospitals in Indonesia, including Dr. Cipto Mangunkusumo Hospital (Jakarta), Dr. Kariadi Hospital (Semarang), and Dr. Soetomo Hospital (Surabaya), enrolling those diagnosed with cIAIs. Blood specimens were collected before or after at least 72 h of the last antibiotic administration. Meanwhile, tissue biopsy/aspirate specimens were collected intraoperatively. These specimens were cultured, followed by a susceptibility test for specific pathogens. The minimum inhibitory concentration (MIC) of isolates was determined according to CLSI M100. Two-hundred-and-eighty-four patients were enrolled from 2019-2021. Blood culture was dominated by Gram-positive bacteria (GPB, n = 25, 52.1%), whereas abdominal tissue culture was dominated by Gram-negative bacteria (GNB, n = 268, 79.5%). The three most common organisms were GNB, including E. coli , K. pneumoniae , and P. aeruginosa . C/T was susceptible in 96.7%, 70.2%, and 94.1% of the E. coli , K. pneumoniae , and P. aeruginosa isolates, respectively. In addition, C/T also remained active against ESBL Enterobacterales and carbapenem-non-susceptible P. aeruginosa . Overall, C/T demonstrates a high potency against GNB isolates and can be considered an agent for carbapenem-sparing strategy for cIAI patients as the susceptibility is proven. |
