Neuromuscular Weakness and Paralysis Produced by Snakebite Envenoming: Mechanisms and Proposed Standards for Clinical Assessment.

Autor: Bickler PE; Center for Exploration and Travel Health, California Academy of Science, San Francisco, CA 94118, USA.; Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Ave, Medical Science Room S-257, San Francisco, CA 94143-0542, USA., Abouyannis M; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Bhalla A; Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India., Lewin MR; Center for Exploration and Travel Health, California Academy of Science, San Francisco, CA 94118, USA.; Ophirex, Inc., Corte Madera, CA 94925, USA.
Jazyk: angličtina
Zdroj: Toxins [Toxins (Basel)] 2023 Jan 06; Vol. 15 (1). Date of Electronic Publication: 2023 Jan 06.
DOI: 10.3390/toxins15010049
Abstrakt: Respiratory and airway-protective muscle weakness caused by the blockade of neuromuscular transmission is a major cause of early mortality from snakebite envenoming (SBE). Once weakness is manifest, antivenom appears to be of limited effectiveness in improving neuromuscular function. Herein, we review the topic of venom-induced neuromuscular blockade and consider the utility of adopting clinical management methods originally developed for the safe use of neuromuscular blocking agents by anesthesiologists in operating rooms and critical care units. Failure to quantify neuromuscular weakness in SBE is predicted to cause the same significant morbidity that is associated with failure to do so in the context of using a clinical neuromuscular block in surgery and critical care. The quantitative monitoring of a neuromuscular block, and an understanding of its neurophysiological characteristics, enables an objective measurement of weakness that may otherwise be overlooked by traditional clinical examination at the bedside. This is important for the initial assessment and the monitoring of recovery from neurotoxic envenoming. Adopting these methods will also be critical to the conduct of future clinical trials of toxin-inhibiting drugs and antivenoms being tested for the reversal of venom-induced neuromuscular block.
Databáze: MEDLINE
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