Effect of 'Arogyavardhini' against carbon tetrachloride induced hepatic damage in albino rats.

Autor: Dange SV; Department of Pharmacology, B. J. Medical College, Pune., Patki PS, Bapat VM, Shrotri DS
Jazyk: angličtina
Zdroj: Indian journal of physiology and pharmacology [Indian J Physiol Pharmacol] 1987 Jan-Mar; Vol. 31 (1), pp. 25-9.
Abstrakt: 'Arogyavardhini'-an indigenous formulation was evaluated for its hepatoprotective activity in rats, using two models of carbon tetrachloride (CCl4) hepatic damage, one simulating vital hepatitis and the other simulating fatty change. The protective effect was assessed from serum aspartate transaminase (AST) and alkaline phosphatase levels and from histopathological changes in liver. The results revealed that 'Arogyavardhini' (5 mg/100g, PO daily) was effective in minimizing the changes in serum levels of AST and alkaline phosphatase induced by CCI. The protective effect was also evident on histopathological examination.
Databáze: MEDLINE