Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats.

Autor: Salaheldin AT; Department of Biotechnology, Faculty of Sciences, Cairo University, Giza 12613, Egypt., Shehata MR; Chemistry Department, Faculty of Sciences, Cairo University, Giza 12613, Egypt., Sakr HI; Department of Medical Physiology, Faculty of Medicine, Cairo University, Giza 12613, Egypt.; Department of Medical Physiology, Medicine Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia., Atia T; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 16273, Saudi Arabia., Mohamed AS; Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
Jazyk: angličtina
Zdroj: Marine drugs [Mar Drugs] 2022 Dec 28; Vol. 21 (1). Date of Electronic Publication: 2022 Dec 28.
DOI: 10.3390/md21010025
Abstrakt: Peptic ulcer is a widespread disease, with a lifetime frequency of 5−10% among the general population and an annual incidence of 0.1−0.3%. Ovothiol A is naturally produced from sea urchin eggs with special antioxidant activity. Gastric ulcers were induced in rats by a single ethanol dose (5 mL/kg). The rats were divided into control, ulcer, and ulcer with 250 and 500 mg/kg ovothiol A doses. Molecular docking studies were used to examine the interactions between ovothiol A and the H+/K+ ATPase active site residues. Ovothiol A led to a significant decline (p < 0.05) in gastric juice volume, ulcer index, MDA, IL-6, and cytochrome c, while levels of gastric juice pH, GSH, CAT, GST, SOD, and NO increased. Histopathological investigation of stomach sections revealed architecture preservation of the gastric mucosa after ovothiol A administration. The anti-ulcerogenic activity of ovothiol A includes scavenging free radicals, inhibition of inflammation, regulation of apoptosis, and stabilization of fibroblast growth factors to promote gastric ulcers healing.
Databáze: MEDLINE