Severe Acute Respiratory Syndrome Coronavirus-2 Delta Variant Study In Vitro and Vivo.

Autor:	Avagyan H; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia.; Experimental Laboratory, Yerevan State Medical University, 2 Koryun St, Yerevan 0025, Armenia., Hakobyan S; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia., Poghosyan A; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia., Hakobyan L; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia., Abroyan L; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia., Karalova E; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia.; Experimental Laboratory, Yerevan State Medical University, 2 Koryun St, Yerevan 0025, Armenia., Avetisyan A; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia.; Experimental Laboratory, Yerevan State Medical University, 2 Koryun St, Yerevan 0025, Armenia., Sargsyan M; Department of Epidemiology and Parasitology, Armenian National Agrarian University, 74 Teryan St, Yerevan 0009, Armenia., Baghdasaryan B; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia., Bayramyan N; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia., Avetyan D; Laboratory of Human Genomics and Immunomics, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia., Karalyan Z; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 7 Hasratyan St, Yerevan 0014, Armenia.; Department of Medical Biology, Yerevan State Medical University, 2 Koryun St, Yerevan 0025, Armenia.
Jazyk:	angličtina
Zdroj:	Current issues in molecular biology [Curr Issues Mol Biol] 2022 Dec 30; Vol. 45 (1), pp. 249-267. Date of Electronic Publication: 2022 Dec 30.
DOI:	10.3390/cimb45010019
Abstrakt:	At the end of 2019, an outbreak of a new severe acute respiratory syndrome caused by a coronavirus occurred in Wuhan, China, after which the virus spread around the world. Here, we have described the adaptive capacity and pathogenesis of the SARS-CoV-2 Delta variant, which is widespread in Armenia, in vitro and vivo on Syrian hamsters. We have studied the changes in the SARS-CoV-2genome using viral RNA sequencing during virus adaptation in vitro and in vivo. Our findings revealed that SARS-CoV-2 in Syrian hamsters causes a short-term pulmonary form of the disease, the first symptoms appear within 48 h after infection, reach 5-7 days after infection, and begin to disappear by 7-9 days after infection. The virus induces pathogenesis in the blood and bone marrow, which generally corresponds to the manifestation of the inflammatory process. The pulmonary form of the disease passes faster than changes in blood cells and bone marrow. Our data show that hamster organs do not undergo significant pathological changes in the Delta variant of SARS-CoV-2 infection.
Databáze:	MEDLINE
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