| Autor: |
Bui Thi Thuy L; Hanoi University of Pharmacy, Hanoi, Vietnam., Vu Thanh B; Hanoi University of Pharmacy, Hanoi, Vietnam., Nguyen Thuy D; Hanoi University of Pharmacy, Hanoi, Vietnam., Chu Thi Thanh H; Hanoi University of Pharmacy, Hanoi, Vietnam., Ha Van O; Hanoi University of Pharmacy, Hanoi, Vietnam., Nguyen Phuong T; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Nguyen Manh T; Hanoi University of Pharmacy, Hanoi, Vietnam. |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2023 Nov-Dec; Vol. 37 (24), pp. 4121-4130. Date of Electronic Publication: 2023 Jan 20. |
| DOI: |
10.1080/14786419.2023.2169864 |
| Abstrakt: |
One new compound, 4,7-dihydroxy-2-hydroxymethyl-5,6-dimethoxyanthraquinone ( 1 ), along with eight known compounds ( 2 - 9 ) were isolated from the methanol extracts of the aerial parts of Chamaecrista pumila (Lam.) K. Larsen. Their chemical structure was determined based on spectroscopic data interpretation and comparison with the reported data. The inhibitory effects of them on α -amylase and α -glucosidase were performed. The results showed that compounds 4 , 6 , 8 , and 9 against potent α -glucosidase with the inhibition values of 98.14 ± 0.05, 98.19 ± 0.04, 97.01 ± 0.49, 84.43 ± 0.6% at 50 µ M, respectively. Compounds 4 and 6 displayed significance against α -amylase at 200 µ M with inhibition values of 22.35 ± 1.10 and 60.47 ± 0.91%. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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