| Autor: |
Tufik S; Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brazil., Troncone LR, Braz S, Silva-Filho AR, Neumann BG |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmacology [Eur J Pharmacol] 1987 Aug 11; Vol. 140 (2), pp. 215-9. |
| DOI: |
10.1016/0014-2999(87)90808-9 |
| Abstrakt: |
Yawning behavior was used to evaluate the sensitivity of presynaptic dopamine receptors and postsynaptic acetylcholine receptors of normal and REM sleep-deprived (REMSD) rats. The results show a lowering of the dose-response curve obtained with apomorphine and pilocarpine, as well as a shift to the right in the curve obtained with physostigmine. These results suggest that REMSD induces subsensitization of presynaptic dopamine receptors and/or postsynaptic acetylcholine receptors with different characteristics related to the mechanism of action of the cholinomimetic agent employed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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