Validity of outcome measures used in randomized clinical trials and observational studies in degenerative lumbar spinal stenosis.

Autor: Wertli MM; Division of General Internal Medicine, Department of General Internal Medicine, Bern University Hospital, Bern University, 3010, Bern, Switzerland. Maria.Wertli@insel.ch.; Horten Centre, University of Zurich, Zurich, Switzerland. Maria.Wertli@insel.ch.; Department of Internal Medicine, Kantonsspital Baden, Baden, Switzerland. Maria.Wertli@insel.ch., Rossi D; Horten Centre, University of Zurich, Zurich, Switzerland.; MedX Notfallpraxis, Zurich, Switzerland., Burgstaller JM; Institute of Primary Care, University of Zurich and University Hospital Zurich, Zurich, Switzerland., Held U; Horten Centre, University of Zurich, Zurich, Switzerland.; Department of Biostatistics at Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland., Ulrich NH; Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland., Farshad M; Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland., Steurer J; Horten Centre, University of Zurich, Zurich, Switzerland., Brunner F; Department of Physical Medicine and Rheumatology, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jan 19; Vol. 13 (1), pp. 1068. Date of Electronic Publication: 2023 Jan 19.
DOI: 10.1038/s41598-022-27218-3
Abstrakt: It is unclear whether outcome measures used in degenerative lumbar spinal stenosis (DLSS) have been validated for this condition. Cross-sectional analysis of studies for DLSS included in systematic reviews (SA) and meta-analyses (MA) indexed in the Cochrane Library. We extracted all outcome measures for pain and disability. We assessed whether the studies provided external references for the validity of the outcome measures and the quality of the validation studies. Out of 20 SA/MA, 95 primary studies used 242 outcome measures for pain and/or disability. Most commonly used were the VAS (n = 69), the Oswestry Disability Index (n = 53) and the Zurich Claudication Questionnaire (n = 22). Although validation references were provided in 45 (47.3%) primary studies, only 14 validation studies for 9 measures (disability n = 7, pain and disability combined n = 2) were specifically validated in a DLSS population. The quality of the validation studies was mainly poor. The Zurich Claudication Questionnaire was the only disease specific tool with adequate validation for assessing treatment response in DLSS. To compare results from clinical studies, outcome measures need to be validated in a disease specific population. The quality of validation studies need to be improved and the validity in studies adequately cited.
(© 2023. The Author(s).)
Databáze: MEDLINE
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