NIR-degradable and biocompatible hydrogels derived from hyaluronic acid and coumarin for drug delivery and bio-imaging.

Autor: Gulfam M; Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea., Jo SH; Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea., Vu TT; Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea., Ali I; Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea., Rizwan A; Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea., Joo SB; Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea., Park SH; Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea; Major of Biomedical Engineering, Division of Smart Healthcare, College of Information Technology and Convergence, Pukyong National University, Busan 48513, Republic of Korea. Electronic address: shpark1@pknu.ac.kr., Lim KT; Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea; Department of Display Engineering, Pukyong National University, Busan 48513, Republic of Korea. Electronic address: ktlim@pknu.ac.kr.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2023 Mar 01; Vol. 303, pp. 120457. Date of Electronic Publication: 2022 Dec 14.
DOI: 10.1016/j.carbpol.2022.120457
Abstrakt: In this work, bioorthogonal and photodegradable hydrogels derived from norbornene (Nb) functionalized hyaluronic acid and a water soluble coumarin-based cross-linker possessing terminal tetrazine (Tz) groups, were developed for NIR-responsive release of doxorubicin (DOX). The inverse electron demand Diels-Alder cross-linking reaction between Nb and Tz functionalities formed the hydrogels at physiological conditions, whereas N 2 gas liberated during the reaction created pores in the hydrogels. The gelation time ranges (about 5-20 min) and the viscoelastic behavior (G' ~ 346-1380 Pa) demonstrated that the resulting hydrogels were injectable and possessed tunable mechanical properties. Moreover, hydrogels released the encapsulated DOX upon NIR irradiation, owing to the NIR-responsive cleavage of coumarin-ester, and consequently, induced anti-tumor activity in BT-20 cancer cells. Additionally, the hydrogels could be excited at various wavelengths of the visible spectrum and can emit green to red fluorescence, demonstrating their simultaneous photo-responsive drug release and bio-imaging applications.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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