Tissue-resident memory T cells trigger rapid exudation and local antibody accumulation.

Autor: Rosato PC; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA; Geisel School of Medicine at Dartmouth College, Dartmouth Cancer Center, Department of Microbiology and Immunology, Lebanon, NH, USA., Lotfi-Emran S; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Joag V; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Wijeyesinghe S; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Quarnstrom CF; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Degefu HN; Geisel School of Medicine at Dartmouth College, Dartmouth Cancer Center, Department of Microbiology and Immunology, Lebanon, NH, USA., Nedellec R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Schenkel JM; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA., Beura LK; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA; Brown University, Department of Molecular Microbiology and Immunology, Providence, RI, USA., Hangartner L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Masopust D; University of Minnesota, Center for Immunology, Department of Microbiology and Immunology, Minneapolis, MN, USA. Electronic address: masopust@umn.edu.
Jazyk: angličtina
Zdroj: Mucosal immunology [Mucosal Immunol] 2023 Feb; Vol. 16 (1), pp. 17-26. Date of Electronic Publication: 2023 Jan 16.
DOI: 10.1016/j.mucimm.2022.11.004
Abstrakt: Adaptive immunity is didactically partitioned into humoral and cell-mediated effector mechanisms, which may imply that each arm is separate and does not function together. Here, we report that the activation of CD8+ resident memory T cells (T RM ) in nonlymphoid tissues triggers vascular permeability, which facilitates rapid distribution of serum antibodies into local tissues. T RM reactivation was associated with transcriptional upregulation of antiviral signaling pathways as well as Fc receptors and components of the complement cascade. Effects were local, but evidence is presented that T RM in brain and reproductive mucosa are both competent to induce rapid antibody exudation. T RM reactivation in the mouse female genital tract increased local concentrations of virus-specific neutralizing antibodies, including anti-vesicular stomatitis virus, and passively transferred anti-HIV antibodies. We showed that this response was sufficient to increase the efficacy of ex vivo vesicular stomatitis virus neutralization. These results indicate that CD8+ T RM antigen recognition can enhance local humoral immunity.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: