2D shear wave elastography of the rectus femoris muscle in patients with cirrhosis: Feasibility and clinical findings. A pilot study.

Autor: Becchetti C; Department for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland., Lange NF; Department for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Bern, Switzerland., Delgado MG; Department for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland., Brönnimann MP; Department of Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Maurer MH; Department of Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Dufour JF; Department for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland., Berzigotti A; Department for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address: annalisa.berzigotti@insel.ch.
Jazyk: angličtina
Zdroj: Clinics and research in hepatology and gastroenterology [Clin Res Hepatol Gastroenterol] 2023 Mar; Vol. 47 (3), pp. 102080. Date of Electronic Publication: 2023 Jan 16.
DOI: 10.1016/j.clinre.2023.102080
Abstrakt: Background and Aims: Frailty is frequent in cirrhosis and associated with skeletal muscle abnormalities and worse prognosis. 2D shear-wave elastography (2D-SWE) could mirror biomechanical properties of skeletal muscle reflecting muscle quality. However, there is no data on 2D-SWE on skeletal muscle stiffness assessment in cirrhosis and on frailty.
Methods: Outpatients with cirrhosis were prospectively included in a single center. Skeletal muscle stiffness was studied at the rectus femoris by 2D-SWE. Ileo-psoas area and index (area/height 2 ), and antero-posterior diameter of rectus femoris (RF) was measured on ultrasound.
Results: We included 44 patients (24 male, age 59 [IQR 49-66]) with a median liver frailty index (LFI) of 3.7 (IQR 3.2-4.0). Measurement of RF muscle stiffness (RFMS) was feasible in all with high inter-measurement reproducibility. RFMS did not correlate with LFI, liver function and skeletal muscle diameters. Ileo-psoas index was lower in frail patients (1.7 vs 1.0 cm 2 /m 2 , p = 0.024). RF antero-posterior diameter inversely correlated with LFI (r -0.578: p<0.001).
Conclusion: RFMS by 2D-SWE is feasible and reproducible in cirrhosis and is independent of liver function and LFI, and warrants further studies in this setting. RF antero-posterior diameter could be reported as an objective parameter mirroring sarcopenia and frailty.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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