| Autor: |
Hart MH; Department of Pediatrics, University of Nebraska Medical Center, Omaha., Phares CK, Erdman SH, Grandjean CJ, Park JH, Vanderhoof JA |
| Jazyk: |
angličtina |
| Zdroj: |
Digestive diseases and sciences [Dig Dis Sci] 1987 Nov; Vol. 32 (11), pp. 1275-80. |
| DOI: |
10.1007/BF01296378 |
| Abstrakt: |
Postresection villus hyperplasia is a major compensatory mechanism in the short-bowel patient. Substances capable of augmenting postresection mucosal hyperplasia could have therapeutic implications. Human growth hormone (hGH) and human growth hormone releasing factor (hGHRF) stimulate growth of the gastrointestinal tract; however, the diabetogenic actions of growth hormone limit its usefulness in clinical practice. Plerocercoid larvae of the tapeworm Spirometra mansonoides produce an analog of hGH void of diabetogenic side effects. We assessed effects of plerocercoid growth factor (PGF) on mucosal adaptation following 70% proximal jejunoileal resection in young rats. Mucosal weight, DNA, protein, and total sucrase activity per centimeter of bowel were increased in resected PGF-treated animals compared to resected controls. We conclude PGF augments intrinsic postresection mucosal hyperplasia following extensive intestinal resection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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