Associations of the COVID-19 pandemic with quality of life: A cross-sectional study of older-age people with and without HIV in rural Uganda.

Autor:	Olivieri-Mui B; Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, USA., Hoeppner SS; College of Science and Mathematics, University of Massachusetts Boston, Boston, USA.; Harvard Medical School, Boston, USA.; Department of Psychiatry, Massachusetts, General Hospital, Boston, USA., Tong Y; Medical Practice Evaluation Center, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, USA., Kohrt E; Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, USA., Quach LT; Medical Practice Evaluation Center, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, USA., Saylor D; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA., Seeley J; Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, United Kingdom., Tsai AC; Harvard Medical School, Boston, USA.; Department of Psychiatry, Massachusetts, General Hospital, Boston, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA., Reynolds Z; Medical Practice Evaluation Center, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, USA., Okello S; Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA.; Mbarara University of Science and Technology., Asiimwe S; Medical Practice Evaluation Center, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, USA.; Mbarara University of Science and Technology.; Kabwohe Clinical Research Centre, Kabwohe Town, Uganda., Flavia A; Mbarara University of Science and Technology., Sentongo R; Mbarara University of Science and Technology., Tindimwebwa E; Kabwohe Clinical Research Centre, Kabwohe Town, Uganda., Meyer AC; Denali Therapeutics, Inc., South San Francisco, California, USA., Nakasujja N; Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda., Paul R; Department of Psychological Sciences, University of Missouri-St Louis, St. Louis, USA., Ritchie C; Harvard Medical School, Boston, USA.; Division of Palliative Care and Geriatric Medicine, Department of Medicine, Massachusetts General Hospital, Boston, USA.; Center for Aging and Serious Illness, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, USA., Greene M; Division of Geriatrics, Department of Medicine, University of California at San Francisco, San Francisco, USA., Siedner MJ; Harvard Medical School, Boston, USA.; Medical Practice Evaluation Center, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, USA.; Mbarara University of Science and Technology.
Jazyk:	angličtina
Zdroj:	Journal of global health [J Glob Health] 2023 Jan 20; Vol. 13, pp. 06003. Date of Electronic Publication: 2023 Jan 20.
DOI:	10.7189/jogh.13.06003
Abstrakt:	Background: COVID-19-related lockdowns and other public health measures may have differentially affected the quality of life (QOL) of older people with and without human immunodeficiency virus (HIV) in rural Uganda. Methods: The Quality of Life and Aging with HIV in Rural Uganda study enrolled people with and without HIV aged over 49 from October 2020 to October 2021. We collected data on COVID-19-related stressors (behavior changes, concerns, interruptions in health care, income, and food) and the participants' QOL. We used linear regression to estimate the associations between COVID-19-related stressors and QOL, adjusting for demographic characteristics, mental and physical health, and time before vs after the lockdown during the second COVID-19 wave in Uganda. Interaction between HIV and COVID-19-related stressors evaluated effect modification. Results: We analyzed complete data from 562 participants. Mean age was 58 (standard deviation (SD) = 7); 265 (47%) participants were female, 386 (69%) were married, 279 (50%) had HIV, and 400 (71%) were farmers. Those making ≥5 COVID-19-related behavior changes compared to those making ≤2 had worse general QOL (estimated linear regression coefficient (b) = - 4.77; 95% confidence interval (CI) = -6.61, -2.94) and health-related QOL (b = -4.60; 95% CI = -8.69, -0.51). Having access to sufficient food after the start of the COVID-19 pandemic (b = 3.10, 95% CI = 1.54, 4.66) and being interviewed after the start of the second lockdown (b = 2.79, 95% CI = 1.30, 4.28) were associated with better general QOL. Having HIV was associated with better health-related QOL (b = 5.67, 95% CI = 2.91,8.42). HIV was not associated with, nor did it modify the association of COVID-19-related stressors with general QOL. Conclusions: In the context of the COVID-19 pandemic in an HIV-endemic, low-resource setting, there was reduced QOL among older Ugandans making multiple COVID-19 related behavioral changes. Nonetheless, good QOL during the second COVID-19 wave may suggest resilience among older Ugandans. Competing Interests: Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. (Copyright © 2023 by the Journal of Global Health. All rights reserved.)
Databáze:	MEDLINE
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