Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study.

Autor:	Hedin K; Futurum, Region Jönköping County, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Department of Clinical Sciences in Malmö, Family Medicine, Lund University, Malmö, Sweden., van der Velden AW; Julius Center of Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Hansen MP; Center for General Practice at, Aalborg University, Aalborg, Denmark., Moberg AB; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Balan A; Balan Medfarm SRL, Cluj Napoca, Romania., Bruno P; Département de Santé Publique, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France., Coenen S; Centre for General Practice, Department of Family Medicine & Population Health, University of Antwerp, Antwerp (Wilrijk), Belgium., Johansen E; Center for General Practice at, Aalborg University, Aalborg, Denmark., Kowalczyk A; Centre for Family and Community Medicine, the Faculty of Health Sciences, the Medical University of Lodz, Lodz, Poland., Kurotschka PK; Department of General Practice, University Hospital Würzburg, Würzburg, Germany., van der Linde SR; Julius Center of Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Malania L; National Center for Disease Control and Public Health, Tbilisi, Georgia., Rohde J; Department of General Practice, University Hospital Würzburg, Würzburg, Germany., Verbakel J; EPI-Centre, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Vornhagen H; Data Science Institute, National University of Galway, Galway, Ireland., Vellinga A; School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Jazyk:	angličtina
Zdroj:	The European journal of general practice [Eur J Gen Pract] 2023 Dec; Vol. 29 (2), pp. 2154074. Date of Electronic Publication: 2023 Jan 19.
DOI:	10.1080/13814788.2022.2154074
Abstrakt:	Background: Most studies on long-term follow-up of patients with COVID-19 focused on hospitalised patients. No prospective study with structured follow-up has been performed in non-hospitalised patients with COVID-19. Objectives: To assess long-COVID and post-COVID (WHO definition: symptomatic at least 12 weeks), describe lingering symptoms, their impact on daily activities, and general practice visits and explore risk factors for symptom duration in outpatients. Methods: A prospective study of adult outpatients with confirmed SARS-CoV-2 infection and symptoms consistent with COVID-19 in 11 European countries, recruited during 2020 and 2021 from primary care and the community. Structured follow-up by phone interviews (symptom rating, symptom impact on daily activities and general practice visits) was performed at weeks 2, 4, 8, and 12 by study personnel. Data was analysed descriptively by using correlation matrixes and Cox regression. Results: Of 270 enrolled patients, 52% developed long-COVID and 32% post-COVID-syndrome. When only considering the presence of moderate or (very) severe symptoms at weeks 8 and 12, these percentages were 28% and 18%, respectively. Fatigue was the most often reported symptom during follow-up. The impact of lingering symptoms was most evident in sports and household activities. About half (53%) had at least one general practice contact during follow-up. Obese patients took twice as long to return to usual health (HR: 0.5, 95%CI: 0.3-0.8); no other risk profile could predict lingering symptoms. Conclusion: Long-COVID and post-COVID are also common in outpatients. In 32%, it takes more than 12 weeks to return to usual health.
Databáze:	MEDLINE
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