The Short-Term Outcome of Seizure and Anti-epileptic Use After Cranial Surgery: A Retrospective Record Review.

Autor:	Abdulaziz NH; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Alyami AA; Department of Medicine, King Abdulaziz University/King Abdulaziz University Hospital, Jeddah, SAU., Basuliman AA; Department of Medicine, King Abdulaziz University/King Abdulaziz University Hospital, Jeddah, SAU., Ywsef KA; Department of Medicine, King Abdulaziz University/King Abdulaziz University Hospital, Jeddah, SAU., Alsulami AH; Department of Medicine, King Abdulaziz University/King Abdulaziz University Hospital, Jeddah, SAU., Alyousef MA; Department of Neurological Surgery, King Abdulaziz University Faculty of Medicine, Jeddah, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Jan 13; Vol. 15 (1), pp. e33749. Date of Electronic Publication: 2023 Jan 13 (Print Publication: 2023).
DOI:	10.7759/cureus.33749
Abstrakt:	Objectives The study aims to correlate craniotomies and their effect on epileptic activity and to assess the impact of prophylaxis anti-epileptic drugs (AEDs) used to prevent seizure activity after craniotomy. Method This was a mono-center retrospective review of patients undergoing craniotomy from 2010-2021 at King Abdulaziz University Hospital (KAUH), a tertiary center in Jeddah, Saudi Arabia. The patients were divided into two groups depending on preoperative anti-epileptic drug usage and the occurrence of seizures after the surgery. Out of 192, 24.6% had a seizure before the surgery, while the rest reported no seizure activity. We used descriptive statistics to categorize the study population and applied t-test and chi-square to compare different groups and outcomes. Results One-hundred-ninety-two patients were studied: 24.6% had preoperative seizure history and 82.1% were on prophylactic AEDs. The incidence of post-craniotomy seizures was 7.6% in patients with anti-epileptic prophylaxis and 2.7% in those without prophylaxis before the surgery. Almost three-quarters of the patients (72.4%) had surgery for brain tumor resection and redo-craniotomy while the rest (25.5%) were for intracranial hemorrhages (p=0.052). On multivariate analysis, the primary predictor of post-craniotomy seizures was the preoperative history of seizures. Finally, the administration of AEDs does not prevent seizure occurrence after craniotomy (p=0.153). Moreover, the type of prophylaxis and reason for the surgery played no significant role in seizure occurrence. Conclusion Post-craniotomy seizures were common, and preoperative AEDs for primary seizure prevention were not associated with a lower incidence of seizures after craniotomy. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Abdulaziz et al.)
Databáze:	MEDLINE
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