A high-sensitivity high-resolution intravascular photoacoustic catheter through mode cleaning in a graded-index fiber.

Autor:	Yuan Y; Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA., Zhang G; Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA., Chen Y; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA., Ni H; Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA., Li M; Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA., Sturek M; CorVus Biomedical, LLC and CorVus Foundation, Inc, Crawfordsville, IN 47933, USA., Cheng JX; Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Jazyk:	angličtina
Zdroj:	Photoacoustics [Photoacoustics] 2023 Jan 06; Vol. 29, pp. 100451. Date of Electronic Publication: 2023 Jan 06 (Print Publication: 2023).
DOI:	10.1016/j.pacs.2023.100451
Abstrakt:	Intravascular photoacoustic imaging has been developed to evaluate the possibility of plaque rupture in atherosclerosis by high spatial resolution imaging of lipid. However, the detection sensitivity and spatial resolution are compromised by the poor focusing caused by a multimode fiber. In this work, we report an intravascular photoacoustic catheter with mode self-cleaning in a graded-index fiber to improve the beam quality and the sensitivity for lipid detection. Compared with the higher-order modes in a step-index multimode fiber, the lower-order modes generated by the self-cleaning effect in the graded-index fiber greatly enhanced the photoacoustic spatial resolution and detection sensitivity. The dominant ringing artifact caused by laser absorption of the ultrasound transducer was further reduced by using stripe suppression. A lipid plaque mimicking phantom was imaged for evaluation. Lipid particles with a small diameter of 75.7 µm were clearly observed. Competing Interests: Ji-Xin Cheng declares a financial interest in Vibronix Inc, which does not support this work. Michael Sturek declares a financial interest in CorVus Biomedical, LLC, which does not support this work. (© 2023 The Authors. Published by Elsevier GmbH.)
Databáze:	MEDLINE
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