Cutaneous cryptococcal infection: Initial manifestation of acquired T-cell immunodeficiency due to malignant thymoma.

Autor: McCann T; Department of Internal Medicine, Good Samaritan Hospital, Cincinnati, Ohio, USA., S Patel A; Department of Infectious Diseases, Good Samaritan Hospital, Cincinnati, Ohio, USA., Patel D N; Department of Internal Medicine, Good Samaritan Hospital, Cincinnati, Ohio, USA., B Sharath D; Department of Internal Medicine, Good Samaritan Hospital, Cincinnati, Ohio, USA., Mansouri B; Department of Internal Medicine, Good Samaritan Hospital, Cincinnati, Ohio, USA., Contreras C; Department of Internal Medicine, Good Samaritan Hospital, Cincinnati, Ohio, USA.
Jazyk: angličtina
Zdroj: Current medical mycology [Curr Med Mycol] 2022 Jun; Vol. 8 (2), pp. 55-58.
DOI: 10.18502/CMM.8.2.10334
Abstrakt: Background and Purpose: Cryptococcosis is a known opportunistic infection. Thymomas are known to cause immune dysregulation. We describe an atypical case of cutaneous cryptococcosis in a patient with acquired T cell immunodeficiency that has been found to be secondary to a type B3 thymoma with progression to carcinoma.
Case Report: A 63-year-old male presented with a chronic skin lesion confirmed as Cryptococcus neoformans on biopsy and an incidental mediastinal mass found during infectious work-up for the notable cluster of differentiation 4 (CD4)+ lymphopenia. This led to the diagnosis of a type B3 thymoma requiring resection. The cryptococcal lesion was treated successfully with azole therapy.
Conclusion: C. neoformans is an opportunistic infection rarely associated with isolated T cell immunodeficiency due to thymomas. A multidisciplinary approach and understanding of the pathogenicity of cryptococcus and the immunological effect of thymic dysfunction are paramount to diagnosis and treatment.
Competing Interests: The authors declare no conflicts of interest.
(Copyright: © 2021, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center.)
Databáze: MEDLINE
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