Is There a Gender Difference in Terms of Inflammatory Biomarkers in Patients With Severe Covid-19 Pneumonia?

Autor:	Akkurt ES; Pulmonary Medicine, Ankara Atatürk Sanatorium Training and Research Hospital, Ankara, TUR., Sahin Ozdemirel T; Pulmonary Medicine, Ankara Ataturk Sanatorium Training and Research Hospital, Ankara, TUR., Ertan O; Pulmonary Medicine, Ankara Atatürk Sanatorium Training and Research Hospital, Ankara, TUR., Unal E; Public Health, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, TUR., Akıncı Özyürek B; Pulmonary Medicine, Ankara Atatürk Sanatorium Training and Research Hospital, Ankara, TUR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Dec 15; Vol. 14 (12), pp. e32541. Date of Electronic Publication: 2022 Dec 15 (Print Publication: 2022).
DOI:	10.7759/cureus.32541
Abstrakt:	Background The men infected with COVID-19 have been shown to have more severe disease and a higher mortality rate. Morbidity and mortality associated with COVID-19 are mediated through intense viral inflammation and increased levels of inflammatory biomarkers. We aimed to retrospectively evaluate any gender difference in patients with severe COVID-19 pneumonia in terms of inflammatory biomarkers. Methods Our study included 132 patients. The general characteristics, radiological features and laboratory parameters of the patients were recorded. Results No difference was observed between the genders according to comorbidities, pulse steroid requirement and hypoxemia. There was no difference between the male and female participants in terms of age, white blood cell count, lymphocyte count, red cell distribution width, C-reactive protein, troponin, albumin and D-dimer. However, duration of hospitalization; percentage of polymorphonuclear leukocyte (PNL); and haemoglobin, alanine aminotransferase and ferritin values were higher in the males, and lymphocyte percentage and platelet count were higher in the women participants. Conclusion Larger studies with gender-specific reporting and robust analyses are required to clarify how gender alters the cellular and molecular pathways associated with COVID-19. This would improve the interpretation of biomarkers and the clinical management of COVID-19 patients by facilitating a personalised medical approach to risk stratification, prevention and treatment. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Akkurt et al.)
Databáze:	MEDLINE
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