Intra-arterial Bevacizumab for Posterior Fossa Hemangioblastoma.
Autor: | Sokol Z; Neurological Surgery, Temple University, Philadelphia, USA.; Neurological Surgery, St. Luke's University Health Network, Bethlehem, USA., Hoeft A; Neurological Surgery, Southern Illinois University School of Medicine, Springfield, USA., Kung D; Neurological Surgery, Cooperman Barnabas Medical Center, Livingston, USA., Belman N; Oncology, St. Luke's University Health Network, Bethlehem, USA., Oselkin M; Radiology, St. Luke's University Health Network, Bethlehem, USA. |
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Jazyk: | angličtina |
Zdroj: | Cureus [Cureus] 2022 Dec 17; Vol. 14 (12), pp. e32624. Date of Electronic Publication: 2022 Dec 17 (Print Publication: 2022). |
DOI: | 10.7759/cureus.32624 |
Abstrakt: | Hemangioblastoma (HB) is a rare, highly vascularized, and benign central nervous system (CNS) tumor. This vascularity is due to a high degree of signaling by vascular endothelial growth factor (VEGF). Consequently, anti-VEGF agents, such as bevacizumab, have been postulated and shown in a few cases to be effective in treating these tumors when surgical therapy is not feasible. Additionally, selective intra-arterial (IA) administration of bevacizumab has shown promise in treating other cancers such as glioblastoma (GBM). Here, we present the case of a 60-year-old female with a symptomatic posterior fossa HB where embolization and surgery were not feasible due to tumor location. She underwent selective IA treatment with bevacizumab, which led to tumor stability and symptomatic improvement. Bevacizumab has been used intravenously (IV) as a treatment for HB, however, its efficacy has not been well-established. This case demonstrates the potential viability of selective bevacizumab in HB, as demonstrated by symptomatic improvement and decreased tumor size on MRI. Further research is needed to demonstrate the specific efficacy of IA bevacizumab for CNS HB when surgery or other treatment modalities are not viable options. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Sokol et al.) |
Databáze: | MEDLINE |
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