Implementation of an integrated care strategy for child contacts of tuberculosis patients: a quasi-experimental study protocol.

Autor:	Benjumea-Bedoya D; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia. dionebenjumea@gmail.com.; Grupo de Investigación en Salud Familiar y Comunitaria, School of Health Sciences, Corporación Universitaria Remington, Medellín, Colombia. dionebenjumea@gmail.com.; Grupo de Epidemiología, Facultad Nacional de Salud Pública, Universidad de Antioquia, Medellín, Colombia. dionebenjumea@gmail.com., Villegas Arbeláez E; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia., Martínez-Peñaloza D; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia., Beltrán-Arroyave CP; Grupo Pediaciencias, Medicine School, Universidad de Antioquia, Medellín, Colombia.; Clínica El Rosario, Medellín, Colombia.; Clínica del Prado, Medellín, Colombia., Restrepo Gouzy AV; Hospital Pablo Tobón Uribe, Medellín, Colombia., Marín D; Grupo de Investigación en Salud Pública, School of Health Sciences, Universidad Pontificia Bolivariana, Medellín, Colombia., Cadavid Álvarez LM; Hospital Pablo Tobón Uribe, Medellín, Colombia., Molinares B; Hospital Pablo Tobón Uribe, Medellín, Colombia., Montes Zuluaga FN; Tuberculosis Program, Secretariat of Health of Medellín, Medellín, Colombia., Pulido Duarte H; Tuberculosis Program, Secretariat of Health of Bello, Bello, Colombia., Suárez Parra PM; Tuberculosis Program, Secretariat of Health of Itagüí, Itagüí, Colombia., Alzate Ángel JC; Grupo de Epidemiología, Facultad Nacional de Salud Pública, Universidad de Antioquia, Medellín, Colombia., Vélez-Parra G; Hospital General de Medellín, Professor Universidad CES, Medellín, Colombia., Realpe T; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia., Vásquez Villa M; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia., Ríos Buitrago SY; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia., Puerta Zapata J; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia., Arango García LM; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia., Perea Torres Y; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia., Pérez Doncel N; School of Health Sciences, Universidad Pontificia Bolivariana, Medellín, Colombia., Arbeláez Montoya MP; Grupo de Epidemiología, Facultad Nacional de Salud Pública, Universidad de Antioquia, Medellín, Colombia., Robledo J; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia.
Jazyk:	angličtina
Zdroj:	BMC pediatrics [BMC Pediatr] 2023 Jan 19; Vol. 23 (1), pp. 28. Date of Electronic Publication: 2023 Jan 19.
DOI:	10.1186/s12887-022-03798-x
Abstrakt:	Background: Childhood tuberculosis continues to be a major public health problem. Although the visibility of the epidemic in this population group has increased, further research is needed. Objective: To design, implement and evaluate an integrated care strategy for children under five years old who are household contacts of bacteriologically confirmed pulmonary tuberculosis patients in Medellín and the Metropolitan Area. Methods: A quasi-experimental study in which approximately 300 children who are household contacts of bacteriologically confirmed pulmonary tuberculosis patients from Medellín and the Metropolitan Area will be evaluated and recruited over one year. A subgroup of these children, estimated at 85, who require treatment for latent tuberculosis, will receive an integrated care strategy that includes: some modifications of the current standardized scheme in Colombia, with rifampicin treatment daily for four months, follow-up under the project scheme with nursing personnel, general practitioners, specialists, professionals from other disciplines such as social work, psychology, and nutritionist. Additionally, transportation and food assistance will be provided to encourage treatment compliance. This strategy will be compared with isoniazid treatment received by a cohort of children between 2015 and 2018 following the standardized scheme in the country. The study was approved by the CIB Research Ethics Committee and UPB. Clinicaltrials: gov identifier NCT04331262. Discussion: This study is expected to contribute to the development of integrated care strategies for the treatment of latent tuberculosis in children. The results will have a direct impact on the management of childhood tuberculosis contributing to achieving the goals proposed by the World Health Organization's End TB Strategy. Trial Registration: ClinicalTrials.gov identifier NCT04331262 . Implementation of an Integrated Care Strategy for Children Contacts of Patients with Tuberculosis. Registered 2 April 2020. (© 2023. The Author(s).)
Databáze:	MEDLINE
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