Adverse cardiovascular and metabolic perturbations among older women: 'fat-craving' hearts.

Autor: Ho JS; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Wong JJ; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore., Gao F; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Wee HN; Duke-NUS Medical School, Singapore, Singapore., Teo LLY; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Ewe SH; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Tan RS; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Ching J; Duke-NUS Medical School, Singapore, Singapore.; KK Research Centre, KK Women's and Children's Hospital, Singapore, Singapore., Chua KV; Duke-NUS Medical School, Singapore, Singapore., Lee LS; Duke-NUS Medical School, Singapore, Singapore., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore., Kovalik JP; Duke-NUS Medical School, Singapore, Singapore.; Singapore General Hospital, Singapore, Singapore., Koh AS; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. angela.koh.s.m@singhealth.com.sg.; Duke-NUS Medical School, Singapore, Singapore. angela.koh.s.m@singhealth.com.sg.
Jazyk: angličtina
Zdroj: Clinical research in cardiology : official journal of the German Cardiac Society [Clin Res Cardiol] 2023 Nov; Vol. 112 (11), pp. 1555-1567. Date of Electronic Publication: 2023 Jan 18.
DOI: 10.1007/s00392-023-02156-w
Abstrakt: Background: Despite known sex-based differences in cardiovascular aging, differences in aging biology are poorly understood. We hypothesize that circulating metabolites studied cross-sectionally with cardiac aging may be associated with cardiovascular changes that distinguish cardiac aging in women.
Methods: A population-based cohort of community men and women without cardiovascular disease from Singapore underwent detailed clinical and echocardiography examinations. Cross-sectional associations between cardiac functional characteristics and metabolomics profiles were examined.
Results: Five hundred sixty-seven adults (48.9% women) participated. Women were younger (72 ± 4.4 years vs 73 ± 4.3 years, p = 0.022), had lower diastolic blood pressures (71 ± 11.0 mmHg vs 76 ± 11.2 mmHg, p < 0.0001, and less likely to have diabetes mellitus (18.0% vs 27.6%, p = 0.013) and smoking (3.8% vs 34.5%, p < 0.001). Body mass indices were similar (24 ± 3.8 kg/m 2 vs 24 ± 3.4 kg/m 2 , p = 0.29), but women had smaller waist circumferences (81 ± 10.1 cm vs 85 ± 9.2 cm, p < 0.001). Women had a significantly higher E/e' ratios (10.9 ± 3.4 vs 9.9 ± 3.3, p = 0.007) and mitral A peak (0.86 ± 0.2 m/s vs 0.79 ± 0.2 m/s, p < 0.001) than men. Among women, lower E/e' ratio was associated with higher levels of C16 (OR 1.019, 95%CI 1.002-1.036, p = 0.029), C16:1 (OR 1.06, 95%CI 1.006-1.118, p = 0.028), serine (OR 1.019, 95%CI 1.002-1.036, p = 0.025), and histidine (OR 1.045, 95%CI 1.013-1.078, p = 0.006). Lower mitral A peak was associated with higher levels of histidine (OR 1.039, 95%CI 1.009-1.070, p = 0.011), isoleucine (OR 1.013, 95%CI 1.004-1.021, p = 0.004), and C20 (OR 1.341, 95%CI 1.067-1.684, p = 0.012).
Conclusion: Impairments in diastolic functions were more frequent among older women compared to men, despite lower prevalence of vascular risk factors and preserved cardiac structure. Cardiac aging in women correlated with metabolites involved in fatty acid oxidation and tricyclic acid cycle fuelling.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
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