In-line Multidimensional NMR Monitoring of Photochemical Flow Reactions.

Autor: Bazzoni M; Nantes Université, CNRS, CEISAM UMR6230, F-4400, Nantes, France., Lhoste C; Nantes Université, CNRS, CEISAM UMR6230, F-4400, Nantes, France., Bonnet J; Nantes Université, CNRS, CEISAM UMR6230, F-4400, Nantes, France., Konan KE; Nantes Université, CNRS, CEISAM UMR6230, F-4400, Nantes, France., Bernard A; Nantes Université, CNRS, CEISAM UMR6230, F-4400, Nantes, France., Giraudeau P; Nantes Université, CNRS, CEISAM UMR6230, F-4400, Nantes, France., Felpin FX; Nantes Université, CNRS, CEISAM UMR6230, F-4400, Nantes, France., Dumez JN; Nantes Université, CNRS, CEISAM UMR6230, F-4400, Nantes, France.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Apr 06; Vol. 29 (20), pp. e202203240. Date of Electronic Publication: 2023 Mar 08.
DOI: 10.1002/chem.202203240
Abstrakt: This work demonstrates the in-line monitoring of a flow photochemical reaction using 1D and ultrafast 2D NMR methods at high magnetic field. The reaction mixture exiting the flow reactor is flown through the NMR spectrometer and directly analyzed. In the case of simple substrates, suitable information can be obtained through 1D 1 H spectra, but for molecules of higher complexity the use of 2D experiments is key to address signal overlaps and assignment issues. Here we show the usefulness of ultrafast 2D COSY experiments acquired in 70 s or less, for the in-line monitoring of photochemical reactions, and the possibility to obtain reliable quantitative information. This is a powerful framework to, for example, efficiently screen reaction conditions.
(© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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