Complementary peptides represent a credible alternative to agrochemicals by activating translation of targeted proteins.

Autor: Ormancey M; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France., Guillotin B; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France.; Micropep Technologies, Auzeville-Tolosane, France., Merret R; Laboratoire Génome et Développement des Plantes, CNRS/UPVD, Perpignan, France., Camborde L; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France., Duboé C; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France., Fabre B; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France., Pouzet C; Fédération de Recherche Agrobiosciences, Interactions et Biodiversité, UT3/CNRS, Auzeville-Tolosane, France., Impens F; VIB Center for Medical Biotechnology, B9052, Ghent, Belgium.; VIB Proteomics Core, B9052, Ghent, Belgium.; Ghent University, Department of Biomolecular Medicine, B9052, Ghent, Belgium., Van Haver D; VIB Center for Medical Biotechnology, B9052, Ghent, Belgium.; VIB Proteomics Core, B9052, Ghent, Belgium.; Ghent University, Department of Biomolecular Medicine, B9052, Ghent, Belgium., Carpentier MC; Laboratoire Génome et Développement des Plantes, CNRS/UPVD, Perpignan, France., Clemente HS; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France., Aguilar M; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France., Lauressergues D; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France.; Micropep Technologies, Auzeville-Tolosane, France., Scharff LB; University of Copenhagen, Department of Plant and Environmental Sciences, Copenhagen, Denmark., Pichereaux C; Fédération de Recherche Agrobiosciences, Interactions et Biodiversité, UT3/CNRS, Auzeville-Tolosane, France.; Institut de Pharmacologie et de Biologie Structurale, CNRS/UT3, Toulouse, France.; Infrastructure nationale de protéomique, ProFI, FR, 2048, Toulouse, France., Burlet-Schiltz O; Institut de Pharmacologie et de Biologie Structurale, CNRS/UT3, Toulouse, France.; Infrastructure nationale de protéomique, ProFI, FR, 2048, Toulouse, France., Bousquet-Antonelli C; Laboratoire Génome et Développement des Plantes, CNRS/UPVD, Perpignan, France., Gevaert K; VIB Center for Medical Biotechnology, B9052, Ghent, Belgium.; Ghent University, Department of Biomolecular Medicine, B9052, Ghent, Belgium., Thuleau P; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France., Plaza S; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France., Combier JP; Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT, Auzeville-Tolosane, France. jean-philippe.combier@univ-tlse3.fr.; Micropep Technologies, Auzeville-Tolosane, France. jean-philippe.combier@univ-tlse3.fr.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Jan 17; Vol. 14 (1), pp. 254. Date of Electronic Publication: 2023 Jan 17.
DOI: 10.1038/s41467-023-35951-0
Abstrakt: The current agriculture main challenge is to maintain food production while facing multiple threats such as increasing world population, temperature increase, lack of agrochemicals due to health issues and uprising of weeds resistant to herbicides. Developing novel, alternative, and safe methods is hence of paramount importance. Here, we show that complementary peptides (cPEPs) from any gene can be designed to target specifically plant coding genes. External application of synthetic peptides increases the abundance of the targeted protein, leading to related phenotypes. Moreover, we provide evidence that cPEPs can be powerful tools in agronomy to improve plant traits, such as growth, resistance to pathogen or heat stress, without the needs of genetic approaches. Finally, by combining their activity they can also be used to reduce weed growth.
(© 2023. The Author(s).)
Databáze: MEDLINE
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