| Autor: |
Dehghani A; Department of Medical Genetics, Faculty of Medical Sciences, 48503Tarbiat Modares University, Tehran, Iran., Pourjafari F; Department of Biology, Faculty of Science, 196469University of Bojnord, Bojnord, Iran., Koohkan F; Neuroscience Research Center, Institute of Neuropharmacology48463Kerman University of Medical Sciences, Kerman, Iran., Haghpanh T; Anatomical Sciences Department, School of Medicine, 48463Kerman University of Medical Sciences, Kerman, Iran., Pourjafari F; Anatomical Sciences Department, School of Medicine, 48463Kerman University of Medical Sciences, Kerman, Iran., Sheibani V; Neuroscience Research Center, Institute of Neuropharmacology48463Kerman University of Medical Sciences, Kerman, Iran., Afarinesh MR; Neuroscience Research Center, Institute of Neuropharmacology48463Kerman University of Medical Sciences, Kerman, Iran. |
| Abstrakt: |
The fungicide mancozeb increases oxygen-free radicals in the central nervous system. As an antioxidant, L-carnitine protects DNA and cell membranes from damage caused by oxygen-free radicals. The present study investigated how L-carnitine affected the acoustic startle response (ASR) in rats exposed to mancozeb. In this experimental study, male Wistar rats were gavaged orally with mancozeb (500, 1000, and 2000 mg/kg), L-carnitine (100, 200, and 400 mg/kg), or L-carnitine (200 mg/kg) + mancozeb (500 mg/kg) three times in 1 week. In the sham group, saline (0.9%, 10 mL/kg) was gavaged at a volume equivalent to that of the drugs. The control group did not receive any treatment. The results showed that locomotor activity and the percentage of prepulse inhibition in the mancozeb groups decreased compared to the sham group while these parameters increased in the L-carnitine group (200 mg/kg) compared to sham rats. In conclusion, mancozeb may increase the risk factor for cognitive diseases such as schizophrenia in people exposed to it while pretreatment with L-carnitine can attenuate the toxic effect. |
