Mucormycosis causing oral and nasal osteonecrosis in a case of acute myeloid leukemia.

Autor: Lisboa ML; Núcleo de Odontologia Hospitalar, Hospital Universitário Professor Polydoro Ernani de São Thiago, HU-UFSC/EBSERH, Florianópolis, SC, Brazil.; Programa, de Pós-Graduação em Odontologia, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Grando LJ; Departamento de Patologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Kretzer SL; Laboratório de Micologia, Hospital Universitário Professor Polydoro Ernani de São Thiago, HU-UFSC/EBSERH, Florianópolis, SC, Brazil., Tomazelli KB; Programa, de Pós-Graduação em Odontologia, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Bianco BC; Programa, de Pós-Graduação em Odontologia, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Santos da Silva MC; Departamento de Análises Clínicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Kosmann C; Secretaria Estadual de Saúde de Santa Catarina, Florianópolis, SC, Brazil., Meurer MI; Departamento de Patologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Jazyk: angličtina
Zdroj: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [Spec Care Dentist] 2023 Sep-Oct; Vol. 43 (5), pp. 727-730. Date of Electronic Publication: 2023 Jan 17.
DOI: 10.1111/scd.12823
Abstrakt: Aims: Mucormycosis is a rare and aggressive fungal infection with a high mortality rate because of its rapidly progressive and destructive nature. The oral cavity is often affected under opportunistic conditions. We report a 34-year-old woman diagnosed with acute myeloid leukemia complained of slight swelling on the right side of her face with toothache and gingival swelling. An incisional biopsy was performed, and the specimen analysis revealed broad aseptate hyphae with a ribbon-like appearance, which is characteristic of opportunistic Mucorales infection.
Methods and Results: The oral lesion worsened, and invasion of the fungal infection into the maxillary sinus, nasal cavity, ethmoidal air cells, and sphenoid and frontal sinuses was observed. Partial maxillectomy was performed concomitantly with the ongoing chemotherapy for leukemia. A maxillofacial prosthesis was used for functional rehabilitation.
Conclusion: Successful management requires a multimodal approach. In this case, the patient required different systemic approaches for treating leukemia and the fungal infection as well as rehabilitation with an obturator prosthesis.
(© 2023 Special Care Dentistry Association and Wiley Periodicals LLC.)
Databáze: MEDLINE
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