Key insights into secondary metabolites from various Chaetomium species.

Autor: Dwibedi V; University Institute of Biotechnology, Chandigarh University, Mohali, India., Rath SK; School of Pharmaceuticals and Population Health Informatics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand-248009, India. skrath1985@gmail.com., Jain S; Department of Biochemistry and Molecular Biology, Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel., Martínez-Argueta N; School of Natural and Environmental Sciences, Molecular Biology and Biotechnology Division , Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.; Centre for Synthetic and Systems Biology, Institute for Bioengineering, University of Edinburgh, Mary Bruck Building 3.11, King's Building, Edinburgh, EH9 3FB, UK., Prakash R; Department of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala-147004, Punjab, India., Saxena S; Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, 147004, Punjab, India., Rios-Solis L; School of Natural and Environmental Sciences, Molecular Biology and Biotechnology Division , Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK. leo.rios@ncl.ac.uk.; Centre for Synthetic and Systems Biology, Institute for Bioengineering, University of Edinburgh, Mary Bruck Building 3.11, King's Building, Edinburgh, EH9 3FB, UK. leo.rios@ncl.ac.uk.
Jazyk: angličtina
Zdroj: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2023 Feb; Vol. 107 (4), pp. 1077-1093. Date of Electronic Publication: 2023 Jan 17.
DOI: 10.1007/s00253-023-12365-y
Abstrakt: Endophytic fungi have proved to be a major source of secondary metabolites, wherein the genus Chaetomium has emerged as a source of multifarious bioactive natural compounds belonging to diverse classes such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, xanthones, anthraquinone, chromones, depsidones, terpenoids, and steroids. The objective of this review is to encapsulate recent findings on various Chaetomium strains, such as C. globosum, C. cupreum, C. elatum, C. subspirale, C. olivaceum, C. indicum, and C. nigricolor known for production of beneficial secondary metabolites, with an insight into their origin and function. A thorough literature survey was conducted for obtaining Chaetomium-derived secondary metabolites, with a scope of future application into drug development efforts. More than 100 secondary metabolites, with various beneficial properties such as antitumor, cytotoxic, antimalarial, and enzyme inhibitory activities, were enlisted. We believe this review will enhance the understanding of beneficial effects conferred by various Chaetomium-derived secondary metabolites and emphasize their potential in serving novel drug development efforts. KEY POINTS: • Identified Chaetomium-derived metabolites with potential for drug development. • More than 100 beneficial metabolites are enlisted. • Benefits include anti-cancerous, antimalarial, and anti-enzymatic properties.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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