Phase-and disorder-specific differences in peripheral metabolites of the kynurenine pathway in major depression, bipolar affective disorder and schizophrenia.

Autor: Brum M; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany., Nieberler M; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Wuerzburg, Wuerzburg, Germany., Kehrwald C; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany., Knopf K; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany., Brunkhorst-Kanaan N; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany., Etyemez S; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany.; Current: Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Allers KA; CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany., Bittner RA; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany.; Ernst Struengmann Institute for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany., Slattery DA; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany., McNeill RV; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany.; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Wuerzburg, Wuerzburg, Germany., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany., Kittel-Schneider S; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University of Frankfurt, Frankfurt, Germany.; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Wuerzburg, Wuerzburg, Germany.
Jazyk: angličtina
Zdroj: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2023 Sep-Oct; Vol. 24 (7), pp. 564-577. Date of Electronic Publication: 2023 Jan 30.
DOI: 10.1080/15622975.2023.2169348
Abstrakt: Objectives: Kynurenine, kynurenic and quinolinic acid are important metabolites in tryptophan metabolism. Due to an involvement in glutamatergic neurotransmission and immune response, previous studies have investigated this pathway in mental disorders such as major depressive disorder (MDD), bipolar disorder (BD) or schizophrenia (SCZ). Tryptophan and kynurenine have been shown to be decreased across disorders, hinting at the missing link how inflammation causes neurotoxicity and psychiatric symptoms. The main aim of our study was to investigate if individual catabolites could serve as diagnostic biomarkers for MDD, BD and SCZ.
Methods: We measured plasma levels of tryptophan, kynurenine, kynurenic acid, quinolinic acid and ratio of quinolinic acid/kynurenic acid using mass spectrometry in n  = 175 participants with acute episodes and after remission, compared with controls.
Results: Decreased levels of all tryptophan catabolites were found in the whole patient group, driven by the difference between BD and HC. Manic and mixed phase BD individuals displayed significantly lower kynurenine and kynurenic acid levels. We could not find significant differences between disorders. Upon reaching remission, changes in catabolite levels partially normalised.
Conclusions: Our data suggests an involvement of the kynurenine pathway in mental disorders, especially BD but disqualifying those metabolites as biomarkers for differential diagnosis.
Databáze: MEDLINE
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