Micro and macroevolution of sea anemone venom phenotype.

Autor: Smith EG; University of North Carolina at Charlotte, Department of Biological Sciences, Charlotte, NC, USA. ed.g.smith@warwick.ac.uk.; School of Life Sciences, University of Warwick, Coventry, United Kingdom. ed.g.smith@warwick.ac.uk., Surm JM; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel. joachim.surm@mail.huji.ac.il., Macrander J; University of North Carolina at Charlotte, Department of Biological Sciences, Charlotte, NC, USA.; Florida Southern College, Biology Department, Lakeland, FL, USA., Simhi A; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel.; The Hebrew University of Jerusalem, The School of Computer Science & Engineering, Jerusalem, Israel., Amir G; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel.; The Hebrew University of Jerusalem, The School of Computer Science & Engineering, Jerusalem, Israel., Sachkova MY; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel.; Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway., Lewandowska M; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel., Reitzel AM; University of North Carolina at Charlotte, Department of Biological Sciences, Charlotte, NC, USA., Moran Y; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Jerusalem, Israel. yehu.moran@mail.huji.ac.il.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Jan 16; Vol. 14 (1), pp. 249. Date of Electronic Publication: 2023 Jan 16.
DOI: 10.1038/s41467-023-35794-9
Abstrakt: Venom is a complex trait with substantial inter- and intraspecific variability resulting from strong selective pressures acting on the expression of many toxic proteins. However, understanding the processes underlying toxin expression dynamics that determine the venom phenotype remains unresolved. By interspecific comparisons we reveal that toxin expression in sea anemones evolves rapidly and that in each species different toxin family dictates the venom phenotype by massive gene duplication events. In-depth analysis of the sea anemone, Nematostella vectensis, revealed striking variation of the dominant toxin (Nv1) diploid copy number across populations (1-24 copies) resulting from independent expansion/contraction events, which generate distinct haplotypes. Nv1 copy number correlates with expression at both the transcript and protein levels with one population having a near-complete loss of Nv1 production. Finally, we establish the dominant toxin hypothesis which incorporates observations in other venomous lineages that animals have convergently evolved a similar strategy in shaping their venom.
(© 2023. The Author(s).)
Databáze: MEDLINE
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