Individual behavioral trajectories shape whole-brain connectivity in mice.

Autor:	Bogado Lopes J; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany.; Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Dresden, Germany., Senko AN; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany.; Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Dresden, Germany., Bahnsen K; Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Dresden, Germany., Geisler D; Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Dresden, Germany., Kim E; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience King's College, London, United Kingdom., Bernanos M; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience King's College, London, United Kingdom., Cash D; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience King's College, London, United Kingdom., Ehrlich S; Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Dresden, Germany.; Department of Child and Adolescent Psychiatry, Faculty of Medicine, Eating Disorder Treatment and Research Center, Dresden, Germany., Vernon AC; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, United Kingdom.; MRC Centre for Neurodevelopmental Disorders, King's College, London, United Kingdom., Kempermann G; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany.; Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Dresden, Germany.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 Jan 16; Vol. 12. Date of Electronic Publication: 2023 Jan 16.
DOI:	10.7554/eLife.80379
Abstrakt:	It is widely assumed that our actions shape our brains and that the resulting connections determine who we are. To test this idea in a reductionist setting, in which genes and environment are controlled, we investigated differences in neuroanatomy and structural covariance by ex vivo structural magnetic resonance imaging in mice whose behavioral activity was continuously tracked for 3 months in a large, enriched environment. We confirmed that environmental enrichment increases mouse hippocampal volumes. Stratifying the enriched group according to individual longitudinal behavioral trajectories, however, revealed striking differences in mouse brain structural covariance in continuously highly active mice compared to those whose trajectories showed signs of habituating activity. Network-based statistics identified distinct subnetworks of murine structural covariance underlying these differences in behavioral activity. Together, these results reveal that differentiated behavioral trajectories of mice in an enriched environment are associated with differences in brain connectivity. Competing Interests: JB, AS, KB, DG, EK, MB, DC, SE, AV, GK No competing interests declared (© 2023, Bogado Lopes et al.)
Databáze:	MEDLINE
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