Co-circulation of all the four Dengue virus serotypes during 2018-2019: first report from Eastern Uttar Pradesh, India.

Autor:	Behera SP; ICMR-Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India., Bhardwaj P; ICMR-Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India., Deval H; ICMR-Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India., Srivastava N; ICMR-Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India., Singh R; ICMR-Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India., Misra BR; ICMR-Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India., Agrawal A; Division of Pathology, Gorakhnath Hospital, Gorakhpur, Uttar Pradesh, India., Kavathekar A; ICMR-Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India., Kant R; ICMR-Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India.
Jazyk:	angličtina
Zdroj:	PeerJ [PeerJ] 2023 Jan 09; Vol. 11, pp. e14504. Date of Electronic Publication: 2023 Jan 09 (Print Publication: 2023).
DOI:	10.7717/peerj.14504
Abstrakt:	Dengue fever is an endemic disease in India, transmitted by an infected mosquito bite. In India, the number of concurrent infections and the circulation of multiple dengue virus (DENV) serotypes has increased in recent decades. Molecular surveillance among the DENV serotype is important to keep track of the circulating serotypes, evolutionary changes, and key mutations that can alter the diagnostics. The current study included patients admitted for dengue in the Eastern Uttar Pradesh (E-UP) region during 2018-2019. The genetic characterization of the circulating DENV was accomplished through partial CprM (511 bp) gene amplification via reverse transcriptase polymerase chain reaction and sequencing. Phylogenetic analysis revealed the circulation of all four DENV1-4 serotypes. DENV-2 was the most abundant serotype (44%, 27/61), followed by DENV-3 (32%, 20/61). DENV-1 had a 16% (10/61) predominance, while DENV-4 (6%, 4/61) was found to be the least abundant serotype. DENV-2 genotypes were distributed among lineages I (7.4%), II (85%) and III (7.4%) of genotype IV, DENV-3 to lineage III of genotype III, DENV-1 to genotype III; DENV-2 to lineage B (75%) and C (25%) of genotype I. This primary report on the co-circulation of DENV1-4 serotypes from the E-UP region highlights the requirement of continuous molecular surveillance for monitoring circulating DENV serotypes. Competing Interests: The authors declare that they have no competing interests. (© 2023 Behera et al.)
Databáze:	MEDLINE
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