Scarring versus Non-Scarring Alopecia: An Interobserver Histopathological Reproducibility Study.

Autor:	Botega AADR; Department of Pathology, School of Medical Sciences, State University of Campinas, Campinas, Brazil., Amorim CV; Department of Pathology, School of Medical Sciences, State University of Campinas, Campinas, Brazil., Teixeira F; Department of Pathology, School of Medical Sciences, State University of Campinas, Campinas, Brazil., Borges Figueira de Mello CD; Department of Dermatology, School of Medical Sciences, State University of Campinas, Campinas, Brazil., Stelini RF; Department of Pathology, School of Medical Sciences, State University of Campinas, Campinas, Brazil., Velho PENF; Department of Dermatology, School of Medical Sciences, State University of Campinas, Campinas, Brazil., Cintra ML; Department of Pathology, School of Medical Sciences, State University of Campinas, Campinas, Brazil.
Jazyk:	angličtina
Zdroj:	Skin appendage disorders [Skin Appendage Disord] 2023 Jan; Vol. 9 (1), pp. 34-41. Date of Electronic Publication: 2022 Nov 25.
DOI:	10.1159/000526966
Abstrakt:	Introduction: Distinguishing scarring (SA) versus non-scarring alopecia (NSA) may not be a simple procedure on either clinical or histopathological views. Aims: We sought to study the interobserver variability in the histopathological assessment of SA versus NSA, including clinical-pathological considerations. Methods: Two dermatopathologists independently interpreted the same set of 100 specimens (89 patients). The samples were serial sectioned and stained by hematoxylin and eosin and Verhöeff methods. The patients' mean age was 46 years, with 13 being males and 76 females. Results: In 16/100 samples, there was no consensus among the two examiners regarding SA versus NSA (weighted kappa = 0.6583; 95% CI); 3/16 patients were re-biopsied, and in the second sample, consensus was reached. In 76/89 patients, the anatomopathological examination was helpful in defining the SA versus NSA subtype. Of the 84 samples in which there was interobserver agreement, 4 which had been considered scarring in the routine pathological report were re-classified as non-scarring, whereas one biopsy, previously diagnosed as non-scarring, was now considered cicatricial due to the newly found areas of lichenoid inflammation in the infundibular epithelium. Discussion: The ideal scalp examination may require deep serial biopsy sectioning, elastic tissue stain, re-biopsy, and strict clinical-evolutive correlation. Competing Interests: The authors declare that they have no conflicts of interest, financial activities, or relationships to disclose, which might have influenced what is written in the submitted manuscript. (Copyright © 2022 by S. Karger AG, Basel.)
Databáze:	MEDLINE
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