A systematic study of nano-based fibrous systems: Diagnostic and therapeutic approaches for dementia control.

Autor: Chehrehgosha M; Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411713137, Iran; Department of Surgical Technology, Paramedical School, Golestan University of Medical Sciences, Gorgan, 4934174515, Iran., Khoshnevisan K; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Research and Development Team, Evolution Wound Dressing (EWD) Startup Co., Tehran, Iran. Electronic address: khoshnevisan.k@sbmu.ac.ir., Maleki H; Research and Development Team, Evolution Wound Dressing (EWD) Startup Co., Tehran, Iran; Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran., Baharifar H; Research and Development Team, Evolution Wound Dressing (EWD) Startup Co., Tehran, Iran; Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran., Meftah AM; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA., Sajjadi-Jazi SM; Research and Development Team, Evolution Wound Dressing (EWD) Startup Co., Tehran, Iran; Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411713137, Iran., Sharifi F; Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411713137, Iran; Research and Development Team, Evolution Wound Dressing (EWD) Startup Co., Tehran, Iran.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2023 Mar; Vol. 85, pp. 101853. Date of Electronic Publication: 2023 Jan 13.
DOI: 10.1016/j.arr.2023.101853
Abstrakt: Nano-based systems provide many advantages, including eluding gastrointestinal and first-pass metabolism of the drug and improving the potential advantage of reduced doses of drugs for an equal or better therapeutic effect compared to other parts of oral administration. Over the last few years, protein-based nanofibrous biomaterials have been used for better controlling dementia. PubMed, Scopus, and ISI Web of Science were consulted for available articles on nano-based fibrous systems for the treatment and diagnosis of dementia (up to October 2022). Of 725 articles that were identified and evaluated, only 19 were included. Eleven studies evaluated nanofibrous electrospun biomaterials for better dementia control. Among these, four investigated marker/biomarker detection for the early diagnosis of dementia. Two from four studies conducted hydrogel-based nanofibrous for Alzheimer's disease (AD) treatment. Additionally, four studies inspected stem cell (SC) transplantation on nano-based fibrous scaffolds for better treatment of dementia. Finally, two from the final four studies considered nano-based fibrous systems for the enhanced treatment of dementia. Our study concluded that nano-based fibrous platforms, exclusively peptide/protein-based nanofibrous scaffolds made from biomaterials, can be applied for dementia management by either diagnostic or therapeutic approaches specific in purpose-designed electrospun nanofibrous scaffolds.
Competing Interests: Competing interests The authors declare that they have no competing interests.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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