Humidity sensors that alert mosquitoes to nearby hosts and egg-laying sites.

Autor:	Laursen WJ; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA., Budelli G; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA., Tang R; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA., Chang EC; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA., Busby R; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA., Shankar S; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA., Gerber R; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA., Greppi C; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA., Albuquerque R; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA., Garrity PA; Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA. Electronic address: pgarrity@brandeis.edu.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2023 Mar 15; Vol. 111 (6), pp. 874-887.e8. Date of Electronic Publication: 2023 Jan 13.
DOI:	10.1016/j.neuron.2022.12.025
Abstrakt:	To reproduce and to transmit disease, female mosquitoes must obtain blood meals and locate appropriate sites for egg laying (oviposition). While distinct sensory cues drive each behavior, humidity contributes to both. Here, we identify the mosquito's humidity sensors (hygrosensors). Using generalizable approaches designed to simplify genetic analysis in non-traditional model organisms, we demonstrate that the ionotropic receptor Ir93a mediates mosquito hygrosensation as well as thermosensation. We further show that Ir93a-dependent sensors drive human host proximity detection and blood-feeding behavior, consistent with the overlapping short-range heat and humidity gradients these targets generate. After blood feeding, gravid females require Ir93a to seek high humidity associated with preferred egg-laying sites. Reliance on Ir93a-dependent sensors to promote blood feeding and locate potential oviposition sites is shared between the malaria vector Anopheles gambiae and arbovirus vector Aedes aegypti. These Ir93a-dependent systems represent potential targets for efforts to control these human disease vectors. Competing Interests: Declaration of interests P.A.G. is a co-inventor on patent WO2017196861A1 (WIPO PCT; pending; inventors: Z. Knecht, P. Garrity, L. Ni) “Methods for modulating insect hygro- and/or thermosensation.” This patent proposes using members of the ionotropic receptor family as targets for strategies to disrupt hygro- and thermo-sensation in insects. W.J.L. and P.A.G. are co-inventors on patent application PCT/US2021/052374, “Sterile organisms, methods of making, and methods of use thereof.” This patent includes methods for genetic manipulations in non-traditional model organisms. (Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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