Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3.

Autor:	McNeill RV; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, Germany. Electronic address: McNeill_R@ukw.de., Radtke F; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, Germany., Nieberler M; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, Germany., Koreny C; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, Germany., Chiocchetti AG; Department of Child and Adolescent Psychiatry and Psychotherapy, Goethe University Frankfurt, Frankfurt am Main, Germany., Kittel-Schneider S; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, Germany; Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital Frankfurt, Frankfurt, Germany.
Jazyk:	angličtina
Zdroj:	Stem cell research [Stem Cell Res] 2023 Mar; Vol. 67, pp. 103016. Date of Electronic Publication: 2023 Jan 05.
DOI:	10.1016/j.scr.2023.103016
Abstrakt:	Single nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSCs from two wild type ADHD patients, and two ADHD patients heterozygous for the risk SNP. With this resource we aim to facilitate further investigation into the complex and heterogenous pathology of ADHD. Furthermore, we demonstrate the feasibility of using magnetic activated cell sorting to allow the unbiased selection of fully reprogrammed iPSCs. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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