Single-cell RNA sequencing identifies a population of human liver-type ILC1s.

Autor:	Krämer B; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany. Electronic address: benjamin.kraemer@ukbonn.de., Nalin AP; Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA., Ma F; Molecular Cell and Developmental Biology, College of Life Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA., Eickhoff S; Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany., Lutz P; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Leonardelli S; Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany., Goeser F; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Finnemann C; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Hack G; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Raabe J; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., ToVinh M; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Ahmad S; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Hoffmeister C; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Kaiser KM; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Manekeller S; Department of Surgery, University of Bonn, 53127 Bonn, Germany., Branchi V; Department of Surgery, University of Bonn, 53127 Bonn, Germany., Bald T; Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany., Hölzel M; Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany., Hüneburg R; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany., Nischalke HD; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany., Semaan A; Department of Surgery, University of Bonn, 53127 Bonn, Germany., Langhans B; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Kaczmarek DJ; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany., Benner B; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA., Lordo MR; Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA., Kowalski J; Nationwide Children's Hospital, Columbus, OH, USA., Gerhardt A; College of Medicine, University of Cincinnati, Cincinnati, OH 45221, USA., Timm J; Institute of Virology, University of Duesseldorf, 40225 Düsseldorf, Germany., Toma M; Department of Pathology, University of Bonn, 53127 Bonn, Germany., Mohr R; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany., Türler A; General and Visceral Surgery, Johanniter Hospital, 53113 Bonn, Germany., Charpentier A; Department of Otorhinolaryngology/Head and Neck Surgery, University of Bonn, 53127 Bonn, Germany; Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, 50931 Cologne, Germany., van Bremen T; Department of Otorhinolaryngology/Head and Neck Surgery, University of Bonn, 53127 Bonn, Germany., Feldmann G; Department of Internal Medicine III, University of Bonn, 53127 Bonn, Germany., Sattler A; Clinic for Surgery, Transplant Immunology Lab, Charité University Hospital Berlin, 10117 Berlin, Germany., Kotsch K; Clinic for Surgery, Transplant Immunology Lab, Charité University Hospital Berlin, 10117 Berlin, Germany., Abdallah AT; Interdisciplinary Center for Clinical Research, RWTH Aachen University, 52074 Aachen, Germany., Strassburg CP; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany., Spengler U; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany., Carson WE 3rd; Division of Surgical Oncology, Department of Surgery, Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA., Mundy-Bosse BL; Division of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA., Pellegrini M; Molecular Cell and Developmental Biology, College of Life Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA., O'Sullivan TE; Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 900953, USA., Freud AG; Department of Pathology, Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address: aharon.freud@osumc.edu., Nattermann J; Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2023 Jan 31; Vol. 42 (1), pp. 111937. Date of Electronic Publication: 2023 Jan 01.
DOI:	10.1016/j.celrep.2022.111937
Abstrakt:	Group 1 innate lymphoid cells (ILCs) comprise a heterogeneous family of cytotoxic natural killer (NK) cells and ILC1s. We identify a population of "liver-type" ILC1s with transcriptional, phenotypic, and functional features distinct from those of conventional and liver-resident NK cells as well as from other previously described human ILC1 subsets. LT-ILC1s are CD49a + CD94 + CD200R1 + , express the transcription factor T-BET, and do not express the activating receptor NKp80 or the transcription factor EOMES. Similar to NK cells, liver-type ILC1s produce IFN-γ, TNF-α, and GM-CSF; however, liver-type ILC1s also produce IL-2 and lack perforin and granzyme-B. Liver-type ILC1s are expanded in cirrhotic liver tissues, and they can be produced from blood-derived ILC precursors in vitro in the presence of TGF-β1 and liver sinusoidal endothelial cells. Cells with similar signature and function can also be found in tonsil and intestinal tissues. Collectively, our study identifies and classifies a population of human cross-tissue ILC1s. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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