Synthesis, characterization, solution chemistry and anticancer activity of [NiCl 2 (Ph 2 P-N(R)-PPh 2 )] (R = 2-CH 2 Py, CH 2 Ph and p-tol) complexes.

Autor: Albuquerque CCV; Department of Chemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, SC, Brazil., Teixeira TM; Department of Genetics, Institute of Biological Sciences, Federal University of Goiás, 74001-970 Goiânia, GO, Brazil., Dos Santos RS; Department of Chemistry, Federal University of Paraná, Polytechnique Center, 81531-980 Curitiba, PR, Brazil., Abreu DC; Department of Genetics, Institute of Biological Sciences, Federal University of Goiás, 74001-970 Goiânia, GO, Brazil., Silveira-Lacerda EP; Department of Genetics, Institute of Biological Sciences, Federal University of Goiás, 74001-970 Goiânia, GO, Brazil., Back DF; Department of Chemistry, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., da Silva JP; Department of Chemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, SC, Brazil., de Araujo MP; Department of Chemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, SC, Brazil; Department of Chemistry, Federal University of Paraná, Polytechnique Center, 81531-980 Curitiba, PR, Brazil. Electronic address: mparaujo@ufpr.br.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2023 Mar; Vol. 240, pp. 112119. Date of Electronic Publication: 2023 Jan 04.
DOI: 10.1016/j.jinorgbio.2023.112119
Abstrakt: In this work three Ni 2+ complexes with general formula [NiCl 2 (Ph 2 P-N(R)-PPh 2 )], R = 2-CH 2 Py (Py = pyridine) - 1, CH 2 Ph (Ph = phenyl) - 2 and p-tol (p-tol = p-tolyl) - 3, were synthesized and characterized. These complexes were obtained in high yield by the reaction of NiCl 2 .6H 2 O and the corresponding diphenylphosphinoamine ligand (Ph 2 P-N(R)-PPh 2 ) in CH 2 Cl 2 /MeOH (1:1) solution, at room temperature (∼25 °C), and characterized by 1 H and 31 P { 1 H} NMR, vibrational spectroscopy in the infrared region, electronic spectroscopy in the UV-Vis regions, elemental analysis (%C, %H, %N) and single-crystal X-ray diffraction. The solution chemistry was studied in CDCl 3 /dmso-d 6 (dimethylsulfoxide) or neat dmso-d 6 using complex 2 as a model. The complexes were evaluated as cytotoxic agents against two cancer cells lines, A549 (lung cancer cells), B16F10 (melanoma cells) and the health cells HaCaT (human epithelial keratinocytes).
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Marcio Peres de Araujo reports financial support was provided by UFPR. Marcio Peres de Araujo reports a relationship with Coordenação de Aperfeiçoamento de Pessoal de Nível Superior that includes: funding grants. Marcio Peres de Araujo reports a relationship with National Council for Scientific and Technological Development that includes: funding grants.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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