Association between Serum α-Klotho Levels and Behçet Disease.
| Autor: | Jafari Nakhjavani MR; Connective Tissue Diseases Research Center., Ghorbanihaghjo A; Biotechnology Research Center., Malek Mahdavi A; Connective Tissue Diseases Research Center.; Tuberculosis and Lung Disease Research Center.; Rahat Breathe and Sleep Research Center., Nemati N; Connective Tissue Diseases Research Center., Rashtchizadeh N; Connective Tissue Diseases Research Center., Abedi Azar S; Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Khabbazi A; Connective Tissue Diseases Research Center. |
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| Jazyk: | angličtina |
| Zdroj: | Laboratory medicine [Lab Med] 2023 Sep 05; Vol. 54 (5), pp. 469-472. |
| DOI: | 10.1093/labmed/lmac146 |
| Abstrakt: | Background: Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behçet disease (BD). α-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED. Objective: To assess serum α-klotho in patients with BD, compared with healthy control individuals. Methods: In a cross-sectional study, 55 patients with BD and 30 age- and sex-matched healthy controls were enrolled, and their serum levels of α-klotho were measured. Results: Common clinical symptoms in patients with BD were oral aphthous ulcers, uveitis, and genital ulcers. Median (IQR) serum α-klotho levels in the BD and control groups were 0.30 (0.20-0.70) and 1.00 (0.70-2.52) ng/mL, respectively. The difference was statistically significant (P = .005). No significant correlation was observed between serum α-klotho and age (r = 0.194; P = .14). Serum α-klotho levels in patients with uveitis were significantly lower. Conclusion: α-klotho may have a role in the pathogenesis of ED and is a potential biomarker for uveitis in BD. (© The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
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