Cerebrovascular pulsatility index is higher in chronic kidney disease.
Autor: | Oh ES; Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Freeberg KA; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Steele CN; Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Wang W; Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Farmer-Bailey H; Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Coppock ME; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Seals DR; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Chonchol M; Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Rossman MJ; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Craighead DH; Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA., Nowak KL; Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. |
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Jazyk: | angličtina |
Zdroj: | Physiological reports [Physiol Rep] 2023 Jan; Vol. 11 (1), pp. e15561. |
DOI: | 10.14814/phy2.15561 |
Abstrakt: | Patients with chronic kidney disease (CKD) are more likely to die of cardiovascular diseases, including cerebrovascular disease, than to progress to end-stage kidney disease. Cerebrovascular dysfunction, characterized by reduced cerebrovascular reactivity, cerebral hypoperfusion, and increased pulsatile flow within the brain, precedes the onset of dementia and is linked to cognitive dysfunction. However, whether impaired cerebrovascular function is present in non-dialysis dependent CKD is largely unknown. Using transcranial Doppler, we compared middle cerebral artery (MCA) blood velocity response to hypercapnia (normalized for blood pressure and end-tidal CO (© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.) |
Databáze: | MEDLINE |
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