IL-22 Promotes Neural Stem Cell Self-Renewal in the Adult Brain.

Autor:	Coronas V; 4CS, Laboratory Channels & Connexins in Cancers and Cell Stemness, CNRS UMR 6041, University of Poitiers, Poitiers, France., Arnault P; 4CS, Laboratory Channels & Connexins in Cancers and Cell Stemness, CNRS UMR 6041, University of Poitiers, Poitiers, France., Jégou JF; LITEC, Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, University of Poitiers, Poitiers, France., Cousin L; 4CS, Laboratory Channels & Connexins in Cancers and Cell Stemness, CNRS UMR 6041, University of Poitiers, Poitiers, France., Rabeony H; LITEC, Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, University of Poitiers, Poitiers, France., Clarhaut S; LITEC, Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, University of Poitiers, Poitiers, France., Harnois T; 4CS, Laboratory Channels & Connexins in Cancers and Cell Stemness, CNRS UMR 6041, University of Poitiers, Poitiers, France., Lecron JC; LITEC, Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, University of Poitiers, Poitiers, France.; Service Immunologie et Inflammation, UBM, CHU de Poitiers, Poitiers, France., Morel F; LITEC, Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, University of Poitiers, Poitiers, France.
Jazyk:	angličtina
Zdroj:	Stem cells (Dayton, Ohio) [Stem Cells] 2023 Mar 17; Vol. 41 (3), pp. 252-259.
DOI:	10.1093/stmcls/sxad003
Abstrakt:	Mainly known for its role in immune defense and inflammation, interleukin 22 (IL-22) has emerged over the past decade as a cytokine involved in the adaptation of stem/progenitor cell activity for tissue homeostasis and repair. IL-22 is present in the brain, which harbors neural stem cells (NSC) in specific niches of which the ventricular-subventricular zone (V-SVZ) is the most important. In this study, we examined a possible effect of IL-22 on NSC in the adult mouse brain. We demonstrate that the IL-22 receptor is expressed in the V-SVZ, mainly in NSC characterized by their SOX2 expression. Addition of IL-22 to V-VSZ cell cultures resulted in an increase in NSC self-renewal, associated with a shift in NSC division mode towards symmetric proliferative divisions at the expense of differentiative divisions. Conversely, loss of IL-22 in knockout mice led to a decrease in neurosphere yield, suggesting a reduction in the NSC population, which was confirmed by the decrease in cells retaining BrdU labeling in IL-22 knockout mice. Our study supports that IL-22 is involved in the development and/or maintenance of V-VSZ NSC and opens new avenues to further investigate the role of IL-22 in NSC biology in health and disease. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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