Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease.

Autor: Weening EH; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Al-Mubarak AA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Dokter MM; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Dickstein K; University of Bergen, Stavanger University Hospital, Stavanger, Norway., Lang CC; Division of Molecular & Clinical Medicine, University of Dundee, Dundee, DD1 9SY, UK., Ng LL; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital and NIHR Leicester Biomedical Research Centre, Leicester, LE3 9QP, UK., Metra M; Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili, University of Brescia, Brescia, Italy., van Veldhuisen DJ; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Touw DJ; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., de Boer RA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Gansevoort RT; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Voors AA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bakker SJL; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van der Meer P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bomer N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. n.bomer@umcg.nl.
Jazyk: angličtina
Zdroj: Cardiovascular diabetology [Cardiovasc Diabetol] 2023 Jan 12; Vol. 22 (1), pp. 8. Date of Electronic Publication: 2023 Jan 12.
DOI: 10.1186/s12933-022-01730-2
Abstrakt: Background: Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food intake and micronutrient metabolism, possibly explaining different health outcomes.
Objective: Our objective was to elucidate sex-specific, cross-sectional phenotypic differences in the association of serum selenium concentrations with parameters of metabolic syndrome and HF.
Methods: We investigated data from individuals from a community-based cohort (PREVEND; N = 4288) and heart failure cohort (BIOSTAT-CHF; N = 1994). In both populations, cross-sectional analyses were performed for potential interaction (p < 0.1) between sex and serum selenium with overlapping signs and clinical parameters of the metabolic syndrome and HF.
Results: Baseline selenium levels of the total cohort were similar between PREVEND (85.7 μg/L) and BIOSTAT-CHF (89.1 μg/L). Females with lower selenium levels had a higher BMI and increased prevalence of diabetes than females with higher selenium, in both PREVEND (p interaction  < 0.001; p interaction  = 0.040, resp.) and BIOSTAT-CHF (p interaction  = 0.021; p interaction  = 0.024, resp.), while opposite associations were observed for males. Additionally, in females, but not in males, lower selenium was associated with a higher prevalence of myocardial infarction (MI) in PREVEND (p interaction  = 0.021) and BIOSTAT-CHF (p interaction  = 0.084).
Conclusion: Lower selenium was associated with a higher BMI and increased prevalence of diabetes in females, opposite to males, and was also associated with more MI in females. Interventional studies are needed to validate this observation.
(© 2023. The Author(s).)
Databáze: MEDLINE
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