A novel pH sensitive theranostic PLGA nanoparticle for boron neutron capture therapy in mesothelioma treatment.

Autor: Sforzi J; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy., Lanfranco A; Department of Chemistry, University of Torino, Via P. Giuria 7, 10125, Turin, Italy., Stefania R; Department of Science and Technological Innovation, Università del Piemonte Orientale, 15121, Alessandria, Italy., Alberti D; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy., Bitonto V; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy., Parisotto S; Department of Chemistry, University of Torino, Via P. Giuria 7, 10125, Turin, Italy., Renzi P; Department of Chemistry, University of Torino, Via P. Giuria 7, 10125, Turin, Italy., Protti N; Department of Physics, University of Pavia, Via Agostino Bassi 6, 27100, Pavia, Italy.; Nuclear Physics National Institute (INFN), Unit of Pavia, Via Agostino Bassi 6, 27100, Pavia, Italy., Altieri S; Department of Physics, University of Pavia, Via Agostino Bassi 6, 27100, Pavia, Italy.; Nuclear Physics National Institute (INFN), Unit of Pavia, Via Agostino Bassi 6, 27100, Pavia, Italy., Deagostino A; Department of Chemistry, University of Torino, Via P. Giuria 7, 10125, Turin, Italy. annamaria.deagostino@unito.it., Geninatti Crich S; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy. simonetta.geninatti@unito.it.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jan 12; Vol. 13 (1), pp. 620. Date of Electronic Publication: 2023 Jan 12.
DOI: 10.1038/s41598-023-27625-0
Abstrakt: This study aims to develop poly lactic-co-glycolic acid (PLGA) nanoparticles with an innovative imaging-guided approach based on Boron Neutron Capture Therapy for the treatment of mesothelioma. The herein-reported results demonstrate that PLGA nanoparticles incorporating oligo-histidine chains and the dual Gd/B theranostic agent AT101 can successfully be exploited to deliver a therapeutic dose of boron to mesothelioma cells, significantly higher than in healthy mesothelial cells as assessed by ICP-MS and MRI. The selective release is pH responsive taking advantage of the slightly acidic pH of the tumour extracellular environment and triggered by the protonation of imidazole groups of histidine. After irradiation with thermal neutrons, tumoral and healthy cells survival and clonogenic ability were evaluated. Obtained results appear very promising, providing patients affected by this rare disease with an improved therapeutic option, exploiting PLGA nanoparticles.
(© 2023. The Author(s).)
Databáze: MEDLINE
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