| Autor: |
Sperling RI; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Weinblatt M, Robin JL, Ravalese J 3rd, Hoover RL, House F, Coblyn JS, Fraser PA, Spur BW, Robinson DR, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Arthritis and rheumatism [Arthritis Rheum] 1987 Sep; Vol. 30 (9), pp. 988-97. |
| DOI: |
10.1002/art.1780300905 |
| Abstrakt: |
Twelve patients with active rheumatoid arthritis supplemented their usual diet with 20 gm of Max-EPA fish oil, daily, for 6 weeks. Following this supplementation, the ratio of arachidonic acid to eicosapentaenoic acid in the patients' neutrophil cellular lipids decreased from 81:1 to 2.7:1, and the mean generation of leukotriene B4 (with calcium ionophore stimulation) significantly declined by 33%. The mean neutrophil chemotaxis to both leukotriene B4 and FMLP significantly increased toward the normal range at week 6. The generation of 5-lipoxygenase products by calcium ionophore-stimulated monocytes was not significantly suppressed, but a significant decline (37%) in platelet-activating factor generation was noted at week 6. The modulation of these measures of leukocyte inflammatory potential suggests that fish oil supplementation may have an antiinflammatory effect. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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