Aberrant corticospinal tract characteristics in prodromal PD: A diffusion tensor imaging study.

Autor:	Pimer LJ; Department of Psychiatry, Dalhousie University, Abbie J. Lane Building, 5909 Veterans' Memorial Lane, Halifax, NS B3H 2E2, Canada., Leslie RA; Department of Psychiatry, Dalhousie University, Abbie J. Lane Building, 5909 Veterans' Memorial Lane, Halifax, NS B3H 2E2, Canada., Phillips G; Division of Respirology, Department of Medicine, Nova Scotia Health Authority, QEII - Halifax Infirmary, Suite 4449 Halifax Infirmary Building, 1796 Summer Street, Halifax, NS B3H 3A7, Canada., Newman AJ; Department of Psychiatry, Dalhousie University, Abbie J. Lane Building, 5909 Veterans' Memorial Lane, Halifax, NS B3H 2E2, Canada.; Department of Psychology and Neuroscience, Dalhousie University, 1355 Oxford Street, Rm 3263, 3rd Floor Life Sciences Centre (Psychology Wing), P.O. Box 15000, Halifax, NS B3H 4R2, Canada., Rusak B; Department of Psychiatry, Dalhousie University, Abbie J. Lane Building, 5909 Veterans' Memorial Lane, Halifax, NS B3H 2E2, Canada.; Department of Psychology and Neuroscience, Dalhousie University, 1355 Oxford Street, Rm 3263, 3rd Floor Life Sciences Centre (Psychology Wing), P.O. Box 15000, Halifax, NS B3H 4R2, Canada., Rolheiser TM; Department of Psychiatry, Dalhousie University, Abbie J. Lane Building, 5909 Veterans' Memorial Lane, Halifax, NS B3H 2E2, Canada., Schoffer K; Division of Neurology, Department of Medicine, Nova Scotia Health Authority, QEII - Halifax Infirmary Site, Suite 3822, Halifax Infirmary Building, 1796 Summer Street, Halifax, NS B3H 3A7, Canada., Khan MN; Department of Radiology, IWK Health Centre, 5850/5980 University Avenue, PO BOX 9700, Halifax, NS B3K 6R8, Canada., McKelvey JR; Division of Neurology, Department of Medicine, Nova Scotia Health Authority, QEII - Halifax Infirmary Site, Suite 3822, Halifax Infirmary Building, 1796 Summer Street, Halifax, NS B3H 3A7, Canada., Robertson HA; Department of Psychiatry, Dalhousie University, Abbie J. Lane Building, 5909 Veterans' Memorial Lane, Halifax, NS B3H 2E2, Canada.; Department of Pharmacology, Dalhousie University, P.O. Box 15000, Halifax, NS B3H 4R2, Canada., Good KP; Department of Psychiatry, Dalhousie University, Abbie J. Lane Building, 5909 Veterans' Memorial Lane, Halifax, NS B3H 2E2, Canada.; Department of Psychology and Neuroscience, Dalhousie University, 1355 Oxford Street, Rm 3263, 3rd Floor Life Sciences Centre (Psychology Wing), P.O. Box 15000, Halifax, NS B3H 4R2, Canada.
Jazyk:	angličtina
Zdroj:	Clinical parkinsonism & related disorders [Clin Park Relat Disord] 2022 Dec 19; Vol. 8, pp. 100182. Date of Electronic Publication: 2022 Dec 19 (Print Publication: 2023).
DOI:	10.1016/j.prdoa.2022.100182
Abstrakt:	Introduction: Parkinson's disease (PD) is typically diagnosed when motor symptoms first occur. However, PD-related non-motor symptoms may appear several years before diagnosis. REM sleep behaviour disorder (RBD) and olfactory deficits (hyposmia) are risk factors, but they are not specific for predicting progression towards PD. Other PD-related markers, for example brain imaging markers, may help to identify preclinical PD in hyposmic RBD patients. Studies have reported abnormal structural characteristics in the corticospinal tract (CST) of PD patients, but it is unclear whether hyposmic RBD patients have similar abnormalities that may help to predict PD in these individuals. This study examined whether CST abnormalities may be a potential marker of PD risk by using diffusion tensor imaging (DTI) measures. Methods: Twenty hyposmic RBD patients, 31 PD patients, and 29 healthy controls (HCs) were studied. DTI data were collected on a 1.5 T MRI scanner and CST characteristics (FA, MD, AD, and RD) were evaluated using probabilistic tractography (with seed regions in the bilateral primary motor cortex and mediolateral cerebral peduncles). Olfactory function was assessed with the University of Pennsylvania Smell Identification Test (UPSIT). Results: Hyposmic RBD patients showed significantly higher mean diffusivity (MD) values of the right CST compared to HCs but did not differ from PD patients. PD patients showed a trend of higher MD values compared to HCs. Conclusions: Altered diffusivity in the CST seems to be associated with RBD. The combination of RBD, hyposmia, and CST alterations may be related to later development of PD with comorbid RBD. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 Published by Elsevier Ltd.)
Databáze:	MEDLINE
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