Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing.

Autor:	du Halgouet A; INSERM U932, PSL University, Institut Curie, 75005 Paris, France., Darbois A; INSERM U932, PSL University, Institut Curie, 75005 Paris, France., Alkobtawi M; Cutaneous Biology, Institut Cochin, Inserm 1016, and Université de Paris Cité, 75014 Paris, France., Mestdagh M; INSERM U932, PSL University, Institut Curie, 75005 Paris, France., Alphonse A; INSERM U932, PSL University, Institut Curie, 75005 Paris, France., Premel V; INSERM U932, PSL University, Institut Curie, 75005 Paris, France., Yvorra T; CNRS UMR 3666, INSERM U1143, Chemical Biology of Cancer Laboratory, PSL University, Institut Curie, 75005 Paris, France., Colombeau L; CNRS UMR 3666, INSERM U1143, Chemical Biology of Cancer Laboratory, PSL University, Institut Curie, 75005 Paris, France., Rodriguez R; CNRS UMR 3666, INSERM U1143, Chemical Biology of Cancer Laboratory, PSL University, Institut Curie, 75005 Paris, France., Zaiss D; Department of Immune Medicine, University of Regensburg, Regensburg, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany; Institute of Pathology, University Regensburg, Regensburg, Germany; Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., El Morr Y; INSERM U932, PSL University, Institut Curie, 75005 Paris, France., Bugaut H; INSERM U932, PSL University, Institut Curie, 75005 Paris, France., Legoux F; INSERM U932, PSL University, Institut Curie, 75005 Paris, France., Perrin L; INSERM U932, PSL University, Institut Curie, 75005 Paris, France., Aractingi S; Cutaneous Biology, Institut Cochin, Inserm 1016, and Université de Paris Cité, 75014 Paris, France., Golub R; Institut Pasteur, Université Paris Cité, INSERM U1223, 75015 Paris, France., Lantz O; INSERM U932, PSL University, Institut Curie, 75005 Paris, France; Laboratoire d'Immunologie Clinique, Institut Curie, 75005 Paris, France; Centre d'investigation Clinique en Biothérapie Gustave-Roussy Institut Curie (CIC-BT1428), Institut Curie, 75005 Paris, France. Electronic address: olivier.lantz@curie.fr., Salou M; INSERM U932, PSL University, Institut Curie, 75005 Paris, France. Electronic address: marion.salou@curie.fr.
Jazyk:	angličtina
Zdroj:	Immunity [Immunity] 2023 Jan 10; Vol. 56 (1), pp. 78-92.e6.
DOI:	10.1016/j.immuni.2022.12.004
Abstrakt:	Tissue repair processes maintain proper organ function following mechanical or infection-related damage. In addition to antibacterial properties, mucosal associated invariant T (MAIT) cells express a tissue repair transcriptomic program and promote skin wound healing when expanded. Herein, we use a human-like mouse model of full-thickness skin excision to assess the underlying mechanisms of MAIT cell tissue repair function. Single-cell RNA sequencing analysis suggested that skin MAIT cells already express a repair program at steady state. Following skin excision, MAIT cells promoted keratinocyte proliferation, thereby accelerating healing. Using skin grafts, parabiosis, and adoptive transfer experiments, we show that MAIT cells migrated into the wound in a T cell receptor (TCR)-independent but CXCR6 chemokine receptor-dependent manner. Amphiregulin secreted by MAIT cells following excision promoted wound healing. Expression of the repair function was probably independent of sustained TCR stimulation. Overall, our study provides mechanistic insights into MAIT cell wound healing function in the skin. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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